Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Christoffer Clemmensen, Sigrid Jail, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis NtziachristosMichael A. Cowley, Brian Finan, Timo D. Mueller, Matthias H. Tschoep

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number4304
Number of pages13
JournalNature Communications
Volume9
DOIs
Publication statusPublished - 23 Oct 2018

Keywords

  • BROWN ADIPOSE-TISSUE
  • OPTIMAL HOUSING TEMPERATURES
  • CENTRAL-NERVOUS-SYSTEM
  • THERMAL ENVIRONMENT
  • ENERGY-EXPENDITURE
  • ACETYLCHOLINE-RECEPTORS
  • OPTOACOUSTIC TOMOGRAPHY
  • BODY-TEMPERATURE
  • HEALTHY-ADULTS
  • TRP CHANNELS
  • Dimethylphenylpiperazinium Iodide/pharmacology
  • Male
  • Receptor, Melanocortin, Type 4/metabolism
  • Fatty Liver/pathology
  • Body Weight/drug effects
  • Cold Temperature
  • Thermogenesis/drug effects
  • Mice, Inbred C57BL
  • Glucose Intolerance/pathology
  • Insulin Resistance
  • Melanocortins/metabolism
  • Pyrimidinones/pharmacology
  • Animals
  • Diabetes Mellitus, Type 2/drug therapy
  • Diet
  • TRPM Cation Channels/antagonists & inhibitors
  • Energy Metabolism/drug effects
  • Mice, Obese
  • Adipose Tissue, Brown/drug effects
  • Receptors, Nicotinic/metabolism
  • Obesity/drug therapy

Cite this

Clemmensen, C., Jail, S., Kleinert, M., Quarta, C., Gruber, T., Reber, J., Sachs, S., Fischer, K., Feuchtinger, A., Karlas, A., Simonds, S. E., Grandl, G., Loher, D., Sanchez-Quant, E., Keipert, S., Jastroch, M., Hofmann, S. M., Nascimento, E. B. M., Schrauwen, P., ... Tschoep, M. H. (2018). Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes. Nature Communications, 9, [4304]. https://doi.org/10.1038/s41467-018-06769-y