Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Christoffer Clemmensen, Sigrid Jail, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis NtziachristosMichael A. Cowley, Brian Finan*, Timo D. Müller*, Matthias H. Tschöp*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number4304
Number of pages13
JournalNature Communications
Volume9
DOIs
Publication statusPublished - 23 Oct 2018

Keywords

  • BROWN ADIPOSE-TISSUE
  • OPTIMAL HOUSING TEMPERATURES
  • CENTRAL-NERVOUS-SYSTEM
  • THERMAL ENVIRONMENT
  • ENERGY-EXPENDITURE
  • ACETYLCHOLINE-RECEPTORS
  • OPTOACOUSTIC TOMOGRAPHY
  • BODY-TEMPERATURE
  • HEALTHY-ADULTS
  • TRP CHANNELS
  • Dimethylphenylpiperazinium Iodide/pharmacology
  • Male
  • Receptor, Melanocortin, Type 4/metabolism
  • Fatty Liver/pathology
  • Body Weight/drug effects
  • Cold Temperature
  • Thermogenesis/drug effects
  • Mice, Inbred C57BL
  • Glucose Intolerance/pathology
  • Insulin Resistance
  • Melanocortins/metabolism
  • Pyrimidinones/pharmacology
  • Animals
  • Diabetes Mellitus, Type 2/drug therapy
  • Diet
  • TRPM Cation Channels/antagonists & inhibitors
  • Energy Metabolism/drug effects
  • Mice, Obese
  • Adipose Tissue, Brown/drug effects
  • Receptors, Nicotinic/metabolism
  • Obesity/drug therapy

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