Convergence of Atomic Charges with the Size of the Enzymatic Environment

Danny E. P. Vanpoucke*, Julianna Olah, Frank De Proft, Veronique Van Speybroeck, Goedele Roos

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Web of Science)

Abstract

Atomic charges are a key concept to give more insight into the electronic structure and chemical reactivity. The Hirshfeld-I partitioning scheme applied to the model protein human 2-cysteine peroxiredoxin thioredoxin peroxidase B is used to investigate how large a protein fragment needs to be in order to achieve convergence of the atomic charge of both neutral and negatively charged residues. Convergence in atomic charges is rapidly reached for neutral residues, but not for negatively charged ones. This study pinpoints difficulties on the road toward accurate modeling of negatively charged residues of large biomolecular systems in a multiscale approach.

Original languageEnglish
Pages (from-to)564-571
Number of pages8
JournalJournal of Chemical Information and Modeling
Volume55
Issue number3
DOIs
Publication statusPublished - Mar 2015
Externally publishedYes

Keywords

  • ELECTRONIC POPULATION ANALYSIS
  • MOLECULAR WAVE FUNCTIONS
  • EXTENDING HIRSHFELD-I
  • PK(A) VALUES
  • FORCE-FIELD
  • DYNAMICS
  • LCAO
  • PARAMETRIZATION
  • SIMULATION
  • PARAMETERS

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