Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors

Danielle B. P. Eekers; Catharina M. L. Zegers; Kamran A. Ahmed; Dante Amelio; Tejpal Gupta; Semi Ben Harrabi; Tomas Kazda; Daniele Scartoni; Clemens Seidel; Helen A. Shih; Giuseppe Minniti

doi:10.1093/nop/npae040

Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors

Danielle B. P. Eekers, Catharina M. L. Zegers, Kamran A. Ahmed, Dante Amelio, Tejpal Gupta, Semi Ben Harrabi, Tomas Kazda, Daniele Scartoni, Clemens Seidel, Helen A. Shih, Giuseppe Minniti^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

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Abstract

Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.

Original language	English
Pages (from-to)	369-382
Number of pages	14
Journal	Neuro-Oncology Practice
Volume	11
Issue number	4
Early online date	1 Apr 2024
DOIs	https://doi.org/10.1093/nop/npae040
Publication status	Published - 1 Aug 2024

Keywords

brain tumors
chordomas
gliomas
meningiomas
proton beam
radiotherapy
radiosurgery
FRACTIONATED STEREOTACTIC RADIOTHERAPY
SKULL BASE CHORDOMAS
LONG-TERM OUTCOMES
GAMMA-KNIFE SURGERY
PHASE-III TRIAL
LOW-GRADE
CLINICAL-OUTCOMES
VESTIBULAR SCHWANNOMA
BENIGN MENINGIOMA
BEAM THERAPY

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10.1093/nop/npae040

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title = "Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors",

abstract = "Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.",

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author = "Eekers, {Danielle B. P.} and Zegers, {Catharina M. L.} and Ahmed, {Kamran A.} and Dante Amelio and Tejpal Gupta and Harrabi, {Semi Ben} and Tomas Kazda and Daniele Scartoni and Clemens Seidel and Shih, {Helen A.} and Giuseppe Minniti",

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language = "English",

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AU - Eekers, Danielle B. P.

AU - Zegers, Catharina M. L.

AU - Ahmed, Kamran A.

AU - Amelio, Dante

AU - Gupta, Tejpal

AU - Harrabi, Semi Ben

AU - Kazda, Tomas

AU - Scartoni, Daniele

AU - Seidel, Clemens

AU - Shih, Helen A.

AU - Minniti, Giuseppe

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AB - Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.

KW - brain tumors

KW - chordomas

KW - gliomas

KW - meningiomas

KW - proton beam

KW - radiotherapy

KW - radiosurgery

KW - FRACTIONATED STEREOTACTIC RADIOTHERAPY

KW - SKULL BASE CHORDOMAS

KW - LONG-TERM OUTCOMES

KW - GAMMA-KNIFE SURGERY

KW - PHASE-III TRIAL

KW - LOW-GRADE

KW - CLINICAL-OUTCOMES

KW - VESTIBULAR SCHWANNOMA

KW - BENIGN MENINGIOMA

KW - BEAM THERAPY

U2 - 10.1093/nop/npae040

DO - 10.1093/nop/npae040

M3 - (Systematic) Review article

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VL - 11

SP - 369

EP - 382

JO - Neuro-Oncology Practice

JF - Neuro-Oncology Practice

IS - 4

ER -

Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors

Abstract

Keywords

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