Controlled-release pregabalin in the treatment of fibromyalgia

Alessandra Alciati, Fabiola Atzeni*, Ignazio Francesco Masala, Mariateresa Cirillo, Davide Sciortino, Giampaolo Perna, Piercarlo Sarzi-Puttini

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Web of Science)

Abstract

Introduction: Fibromyalgia (FM) is a chronic disorder whose symptoms of musculo-skeletal pain, fatigue, sleep disturbances, and cognitive impairment pervade the personal, occupational, and social aspects of a patient's life. Together with the antidepressants duloxetine and milnacipran, the anticonvulsant pregabalin (PGB) is one of the three drugs approved by the Food and Drug Administration for the treatment of FM. The aim of this narrative review is to summarize the data relating to the efficacy and safety of the controlled-release formulation of PGB (PGB-CR) in patients with FM. Areas covered: Efforts by the pharmaceutical industry have led to the introduction of new formulations of already approved drugs to enhance treatment convenience and adherence. Expert opinion: Although there are no published studies specifically comparing PGB-CR and PGB-IR formulations in FM patients, the efficacy and safety profiles of PGB-CR seem to be similar to those of the IR formulation, and the convenience of once-daily dosing potentially enhances patient compliance. However, the amount of evidence is not sufficient to draw any definite conclusions, and further studies of larger patient samples are needed.
Original languageEnglish
Pages (from-to)617-623
Number of pages7
JournalExpert Review of Neurotherapeutics
Volume18
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Fibromyalgia
  • pharmacological treatment
  • pregabalin
  • controlled-release pregabalin
  • HEALTH-CARE COSTS
  • PLACEBO-CONTROLLED TRIAL
  • OF-RHEUMATOLOGY 1990
  • PHASE-III TRIAL
  • DOUBLE-BLIND
  • MEDICATION ADHERENCE
  • DIAGNOSTIC-CRITERIA
  • DULOXETINE
  • PHARMACOKINETICS
  • METAANALYSIS

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