Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis

A. R. Tellegen, I. Rudnik-Jansen, B. Pouran, H. M. de Visser, H. H. Weinans, R. E. Thomas, M. J. L. Kik, G. C. M. Grinwis, J. C. Thies, N. Woike, G. Mihov, P. J. Emans, B. P. Meij, L. B. Creemers, M. A. Tryfonidou

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1438-1447
Number of pages10
JournalDrug Delivery
Volume25
Issue number1
DOIs
Publication statusPublished - Nov 2018

Keywords

  • Drug delivery
  • polyesteramide microspheres
  • synovitis
  • sclerosis
  • cartilage
  • COX-2
  • SELECTIVE COX-2 INHIBITION
  • SUBCHONDRAL BONE
  • RHEUMATOID-ARTHRITIS
  • KNEE OSTEOARTHRITIS
  • HIP OSTEOARTHRITIS
  • DRUG-DELIVERY
  • PAIN
  • RAT
  • RISK
  • HISTOPATHOLOGY
  • Osteoarthritis/drug therapy
  • Bone and Bones/diagnostic imaging
  • Celecoxib/pharmacology
  • Cysts/drug therapy
  • Female
  • Cyclooxygenase 2 Inhibitors/pharmacology
  • Disease Models, Animal
  • Rats
  • Biocompatible Materials/pharmacology
  • Anterior Cruciate Ligament/drug effects
  • Delayed-Action Preparations/pharmacology
  • Animals
  • Osteophyte/drug therapy
  • Inflammation/drug therapy

Cite this

Tellegen, A. R., Rudnik-Jansen, I., Pouran, B., de Visser, H. M., Weinans, H. H., Thomas, R. E., Kik, M. J. L., Grinwis, G. C. M., Thies, J. C., Woike, N., Mihov, G., Emans, P. J., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2018). Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis. Drug Delivery, 25(1), 1438-1447. https://doi.org/10.1080/10717544.2018.1482971