Controlled Human Malaria Infection Trials: How Tandems of Trust and Control Construct Scientific Knowledge

E.M. Bijker, Hans Sauerwein, Wiebe Bijker

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Controlled human malaria infections are clinical trials in which healthy volunteers are deliberately infected with malaria under controlled conditions. Controlled human malaria infections are complex clinical trials: many different groups and institutions are involved, and several complex technologies are required to function together. This functioning together of technologies, people, and institutions is under special pressure because of potential risks to the volunteers. In this article, the authors use controlled human malaria infections as a strategic research site to study the use of control, the role of trust, and the interactions between trust and control in the construction of scientific knowledge. The authors argue that tandems of trust and control play a central role in the successful execution of clinical trials and the construction of scientific knowledge. More specifically, two aspects of tandems of trust and control will be highlighted: tandems are sites where trust and control coproduce each other, and tandems link the personal, the technical, and the institutional domains. Understanding tandems of trust and control results in setting some agendas for both clinical trial research and science and technology studies.

Original languageEnglish
Pages (from-to)56-86
Number of pages31
JournalSocial Studies of Science
Volume46
Issue number1
DOIs
Publication statusPublished - Feb 2016

Keywords

  • CANCER CLINICAL-TRIALS
  • CHALLENGE
  • ERA
  • HEALTH
  • JOURNAL EDITORS
  • RESEARCH ORGANIZATION
  • RESEARCH PARTICIPATION
  • SCIENCE
  • clinical trials
  • control
  • malaria
  • social construction
  • trust

Cite this

@article{0a4b63372512408e8628bc73058f9e44,
title = "Controlled Human Malaria Infection Trials: How Tandems of Trust and Control Construct Scientific Knowledge",
abstract = "Controlled human malaria infections are clinical trials in which healthy volunteers are deliberately infected with malaria under controlled conditions. Controlled human malaria infections are complex clinical trials: many different groups and institutions are involved, and several complex technologies are required to function together. This functioning together of technologies, people, and institutions is under special pressure because of potential risks to the volunteers. In this article, the authors use controlled human malaria infections as a strategic research site to study the use of control, the role of trust, and the interactions between trust and control in the construction of scientific knowledge. The authors argue that tandems of trust and control play a central role in the successful execution of clinical trials and the construction of scientific knowledge. More specifically, two aspects of tandems of trust and control will be highlighted: tandems are sites where trust and control coproduce each other, and tandems link the personal, the technical, and the institutional domains. Understanding tandems of trust and control results in setting some agendas for both clinical trial research and science and technology studies.",
keywords = "CANCER CLINICAL-TRIALS, CHALLENGE, ERA, HEALTH, JOURNAL EDITORS, RESEARCH ORGANIZATION, RESEARCH PARTICIPATION, SCIENCE, clinical trials, control, malaria, social construction, trust",
author = "E.M. Bijker and Hans Sauerwein and Wiebe Bijker",
year = "2016",
month = "2",
doi = "10.1177/0306312715619784",
language = "English",
volume = "46",
pages = "56--86",
journal = "Social Studies of Science",
issn = "0306-3127",
publisher = "SAGE Publications Inc.",
number = "1",

}

Controlled Human Malaria Infection Trials : How Tandems of Trust and Control Construct Scientific Knowledge. / Bijker, E.M.; Sauerwein, Hans; Bijker, Wiebe.

In: Social Studies of Science, Vol. 46, No. 1, 02.2016, p. 56-86.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Controlled Human Malaria Infection Trials

T2 - How Tandems of Trust and Control Construct Scientific Knowledge

AU - Bijker, E.M.

AU - Sauerwein, Hans

AU - Bijker, Wiebe

PY - 2016/2

Y1 - 2016/2

N2 - Controlled human malaria infections are clinical trials in which healthy volunteers are deliberately infected with malaria under controlled conditions. Controlled human malaria infections are complex clinical trials: many different groups and institutions are involved, and several complex technologies are required to function together. This functioning together of technologies, people, and institutions is under special pressure because of potential risks to the volunteers. In this article, the authors use controlled human malaria infections as a strategic research site to study the use of control, the role of trust, and the interactions between trust and control in the construction of scientific knowledge. The authors argue that tandems of trust and control play a central role in the successful execution of clinical trials and the construction of scientific knowledge. More specifically, two aspects of tandems of trust and control will be highlighted: tandems are sites where trust and control coproduce each other, and tandems link the personal, the technical, and the institutional domains. Understanding tandems of trust and control results in setting some agendas for both clinical trial research and science and technology studies.

AB - Controlled human malaria infections are clinical trials in which healthy volunteers are deliberately infected with malaria under controlled conditions. Controlled human malaria infections are complex clinical trials: many different groups and institutions are involved, and several complex technologies are required to function together. This functioning together of technologies, people, and institutions is under special pressure because of potential risks to the volunteers. In this article, the authors use controlled human malaria infections as a strategic research site to study the use of control, the role of trust, and the interactions between trust and control in the construction of scientific knowledge. The authors argue that tandems of trust and control play a central role in the successful execution of clinical trials and the construction of scientific knowledge. More specifically, two aspects of tandems of trust and control will be highlighted: tandems are sites where trust and control coproduce each other, and tandems link the personal, the technical, and the institutional domains. Understanding tandems of trust and control results in setting some agendas for both clinical trial research and science and technology studies.

KW - CANCER CLINICAL-TRIALS

KW - CHALLENGE

KW - ERA

KW - HEALTH

KW - JOURNAL EDITORS

KW - RESEARCH ORGANIZATION

KW - RESEARCH PARTICIPATION

KW - SCIENCE

KW - clinical trials

KW - control

KW - malaria

KW - social construction

KW - trust

U2 - 10.1177/0306312715619784

DO - 10.1177/0306312715619784

M3 - Article

VL - 46

SP - 56

EP - 86

JO - Social Studies of Science

JF - Social Studies of Science

SN - 0306-3127

IS - 1

ER -