TY - JOUR
T1 - Contribution of the 5-HTTLPR gene by neuroticism on weight gain in male and female participants
AU - Markus, C.R.
AU - Capello, A.E.M.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - INTRODUCTION: Reduced brain serotonin (5-HT) function is believed to increase the risk for eating-related disturbances. Differences in 5-HT vulnerability are genetically determined, including a short (S) allele polymorphism in the serotonin transporter gene (5-HTTLPR) that is associated with serotonin dysfunction and is therefore believed to increase the risk for obesity. However, considerable variability has been apparent to replicate these findings. OBJECTIVE: Because reduced control of energy intake often results from distress and negative mood (emotional eating) and because brain 5-HT controls stress adaptation and mood changes, the aim of the current study was to investigate whether the S-allele may particularly contribute toward weight gain in cognitive stress-vulnerable individuals with high neuroticism. METHODS: A total of 857 healthy young male and female college students (21.0+/-2.1 years; BMI 19-25 kg/m) were genotyped for the 5-HTTLPR polymorphism S'/S' (S/S, S/LG, LG/LG), S'/L' (S/La, La/Lg) and L'/L' (LA/LA) and trait neuroticism. The interaction of 5-HTTLPR by neuroticism was assessed on BMI. RESULTS: BMI increased significantly as a function of the presence of the S-allele of 5-HTTLPR only in high neurotic individuals. CONCLUSION: These results indicate that cognitive stress vulnerabilities are critical mediators of the association between 5-HTTLPR and body weight.
AB - INTRODUCTION: Reduced brain serotonin (5-HT) function is believed to increase the risk for eating-related disturbances. Differences in 5-HT vulnerability are genetically determined, including a short (S) allele polymorphism in the serotonin transporter gene (5-HTTLPR) that is associated with serotonin dysfunction and is therefore believed to increase the risk for obesity. However, considerable variability has been apparent to replicate these findings. OBJECTIVE: Because reduced control of energy intake often results from distress and negative mood (emotional eating) and because brain 5-HT controls stress adaptation and mood changes, the aim of the current study was to investigate whether the S-allele may particularly contribute toward weight gain in cognitive stress-vulnerable individuals with high neuroticism. METHODS: A total of 857 healthy young male and female college students (21.0+/-2.1 years; BMI 19-25 kg/m) were genotyped for the 5-HTTLPR polymorphism S'/S' (S/S, S/LG, LG/LG), S'/L' (S/La, La/Lg) and L'/L' (LA/LA) and trait neuroticism. The interaction of 5-HTTLPR by neuroticism was assessed on BMI. RESULTS: BMI increased significantly as a function of the presence of the S-allele of 5-HTTLPR only in high neurotic individuals. CONCLUSION: These results indicate that cognitive stress vulnerabilities are critical mediators of the association between 5-HTTLPR and body weight.
U2 - 10.1097/YPG.0b013e328358632a
DO - 10.1097/YPG.0b013e328358632a
M3 - Article
SN - 0955-8829
VL - 22
SP - 279
EP - 285
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 6
ER -