Continuous infusion of the alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study

Nick P. van Goethem; Jos Prickaerts; Devin Welty; Dorothy G. Flood; Gerhard Koenig

doi:10.1097/FBP.0000000000000134

Continuous infusion of the alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study

Nick P. van Goethem, Jos Prickaerts, Devin Welty, Dorothy G. Flood, Gerhard Koenig

MHeNs - Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Original language	English
Pages (from-to)	403-406
Journal	Behavioural Pharmacology
Volume	26
Issue number	4
DOIs	https://doi.org/10.1097/FBP.0000000000000134
Publication status	Published - Jun 2015

Keywords

acetylcholine
Alzheimer's disease
cognition
episodic memory
EVP-6124
object recognition task
rat
schizophrenia
tolerance
alpha 7 nAChR agonist

Access to Document

10.1097/FBP.0000000000000134

Cite this

van Goethem, N. P., Prickaerts, J., Welty, D., Flood, D. G., & Koenig, G. (2015). Continuous infusion of the alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study. Behavioural Pharmacology, 26(4), 403-406. https://doi.org/10.1097/FBP.0000000000000134

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Continuous infusion of the alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study. / van Goethem, Nick P.; Prickaerts, Jos; Welty, Devin; Flood, Dorothy G.; Koenig, Gerhard.

In: Behavioural Pharmacology, Vol. 26, No. 4, 06.2015, p. 403-406.

Research output: Contribution to journal › Article › Academic › peer-review

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KW - schizophrenia

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KW - alpha 7 nAChR agonist

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