CONTACT HEAT EVOKED POTENTIALS: NORMAL VALUES AND USE IN SMALL-FIBER NEUROPATHY

Vera Lagerburg; Mayienne Bakkers; Anne Bouwhuis; Janneke G. J. Hoeijmakers; Arjen M. Smit; Sofia J. M. Van Den Berg; Ineke Hordijk-De Boer; Mardien D. G. Brouwer-Van Der Lee; Douwe Kranendonk; Jos P. H. Reulen; Catharina G. Faber; Ingemar S. J. Merkies

doi:10.1002/mus.24465

CONTACT HEAT EVOKED POTENTIALS: NORMAL VALUES AND USE IN SMALL-FIBER NEUROPATHY

Vera Lagerburg, Mayienne Bakkers^*, Anne Bouwhuis, Janneke G. J. Hoeijmakers, Arjen M. Smit, Sofia J. M. Van Den Berg, Ineke Hordijk-De Boer, Mardien D. G. Brouwer-Van Der Lee, Douwe Kranendonk, Jos P. H. Reulen, Catharina G. Faber, Ingemar S. J. Merkies

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction Contact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients. Methods: Standardized CHEPs were administered at the wrist and ankle. The N-2 and P-2 latencies and N-2-P-2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n=97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n=42). CHEP reproducibility and interobserver values were also investigated. Results: CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients. Conclusion: In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN. Muscle Nerve, 2015 Muscle Nerve51:743-749, 2015

Original language	English
Pages (from-to)	743-749
Journal	Muscle & Nerve
Volume	51
Issue number	5
DOIs	https://doi.org/10.1002/mus.24465
Publication status	Published - May 2015

Keywords

contact heat evoked potentials
polyneuropathy
quantitative sensory testing
reference values
small-fiber neuropathy

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10.1002/mus.24465

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Lagerburg, V., Bakkers, M., Bouwhuis, A., Hoeijmakers, J. G. J., Smit, A. M., Van Den Berg, S. J. M., Hordijk-De Boer, I., Brouwer-Van Der Lee, M. D. G., Kranendonk, D., Reulen, J. P. H., Faber, C. G., & Merkies, I. S. J. (2015). CONTACT HEAT EVOKED POTENTIALS: NORMAL VALUES AND USE IN SMALL-FIBER NEUROPATHY. Muscle & Nerve, 51(5), 743-749. https://doi.org/10.1002/mus.24465

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title = "CONTACT HEAT EVOKED POTENTIALS: NORMAL VALUES AND USE IN SMALL-FIBER NEUROPATHY",

abstract = "Introduction Contact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients. Methods: Standardized CHEPs were administered at the wrist and ankle. The N-2 and P-2 latencies and N-2-P-2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n=97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n=42). CHEP reproducibility and interobserver values were also investigated. Results: CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients. Conclusion: In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN. Muscle Nerve, 2015 Muscle Nerve51:743-749, 2015",

keywords = "contact heat evoked potentials, polyneuropathy, quantitative sensory testing, reference values, small-fiber neuropathy",

author = "Vera Lagerburg and Mayienne Bakkers and Anne Bouwhuis and Hoeijmakers, {Janneke G. J.} and Smit, {Arjen M.} and {Van Den Berg}, {Sofia J. M.} and {Hordijk-De Boer}, Ineke and {Brouwer-Van Der Lee}, {Mardien D. G.} and Douwe Kranendonk and Reulen, {Jos P. H.} and Faber, {Catharina G.} and Merkies, {Ingemar S. J.}",

year = "2015",

month = may,

doi = "10.1002/mus.24465",

language = "English",

volume = "51",

pages = "743--749",

journal = "Muscle & Nerve",

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T1 - CONTACT HEAT EVOKED POTENTIALS: NORMAL VALUES AND USE IN SMALL-FIBER NEUROPATHY

AU - Lagerburg, Vera

AU - Bakkers, Mayienne

AU - Bouwhuis, Anne

AU - Hoeijmakers, Janneke G. J.

AU - Smit, Arjen M.

AU - Van Den Berg, Sofia J. M.

AU - Hordijk-De Boer, Ineke

AU - Brouwer-Van Der Lee, Mardien D. G.

AU - Kranendonk, Douwe

AU - Reulen, Jos P. H.

AU - Faber, Catharina G.

AU - Merkies, Ingemar S. J.

PY - 2015/5

Y1 - 2015/5

N2 - Introduction Contact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients. Methods: Standardized CHEPs were administered at the wrist and ankle. The N-2 and P-2 latencies and N-2-P-2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n=97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n=42). CHEP reproducibility and interobserver values were also investigated. Results: CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients. Conclusion: In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN. Muscle Nerve, 2015 Muscle Nerve51:743-749, 2015

AB - Introduction Contact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients. Methods: Standardized CHEPs were administered at the wrist and ankle. The N-2 and P-2 latencies and N-2-P-2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n=97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n=42). CHEP reproducibility and interobserver values were also investigated. Results: CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients. Conclusion: In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN. Muscle Nerve, 2015 Muscle Nerve51:743-749, 2015

KW - contact heat evoked potentials

KW - polyneuropathy

KW - quantitative sensory testing

KW - reference values

KW - small-fiber neuropathy

U2 - 10.1002/mus.24465

DO - 10.1002/mus.24465

M3 - Article

C2 - 25256002

SN - 0148-639X

VL - 51

SP - 743

EP - 749

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 5

ER -

CONTACT HEAT EVOKED POTENTIALS: NORMAL VALUES AND USE IN SMALL-FIBER NEUROPATHY

Abstract

Keywords

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