Construct validity of the Post-COVID-19 Functional Status Scale in adult subjects with COVID-19

Felipe V. C. Machado*, Roy Meys, Jeannet M. Delbressine, Anouk W. Vaes, Yvonne M. J. Goertz, Maarten van Herck, Sarah Houben-Wilke, Gudula J. A. M. Boon, Stefano Barco, Chris Burtin, Alex van't Hul, Rein Posthuma, Frits M. E. Franssen, Yvonne Spies, Herman Vijlbrief, Fabio Pitta, Spencer A. Rezek, Daisy J. A. Janssen, Bob Siegerink, Frederikus A. KlokMartijn A. Spruit

*Corresponding author for this work

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32 Citations (Web of Science)

Abstract

Background An increasing number of subjects are recovering from COVID-19, raising the need for tools to adequately assess the course of the disease and its impact on functional status. We aimed to assess the construct validity of the Post-COVID-19 Functional Status (PCFS) Scale among adult subjects with confirmed and presumed COVID-19. Methods Adult subjects with confirmed and presumed COVID-19, who were members of an online panel and two Facebook groups for subjects with COVID-19 with persistent symptoms, completed an online survey after the onset of infection-related symptoms. The number and intensity of symptoms were evaluated with the Utrecht Symptom Diary, health-related quality of life (HrQoL) with the 5-level EQ-5D questionnaire, impairment in work and activities with the Work Productivity and Activity Impairment questionnaire and functional status with the PCFS Scale. Results 1939 subjects were included in the analyses (85% women, 95% non-hospitalized during infection) about 3 months after the onset of infection-related symptoms. Subjects classified as experiencing 'slight', 'moderate' and 'severe' functional limitations presented a gradual increase in the number/intensity of symptoms, reduction of HrQoL and impairment in work and usual activities. No differences were found regarding the number and intensity of symptoms, HrQoL and impairment in work and usual activities between subjects classified as experiencing 'negligible' and 'no' functional limitations. We found weak-to-strong statistical associations between functional status and all domains of HrQoL (r: 0.233-0.661). Notably, the strongest association found was with the 'usual activities' domain of the 5-level EQ-5D questionnaire. Conclusion We demonstrated the construct validity of the PCFS Scale in highly-symptomatic adult subjects with confirmed and presumed COVID-19, 3 months after the onset of symptoms.

Original languageEnglish
Article number40
Number of pages10
JournalHealth and Quality of Life Outcomes
Volume19
Issue number1
DOIs
Publication statusPublished - 3 Feb 2021

Keywords

  • SARS-CoV-2
  • Functional status
  • Symptoms
  • Quality of life

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