Consistent Condom Use Increases the Regression Rate of Cervical Intraepithelial Neoplasia 2-3

Ane Cecilie Munk*, Einar Gudlaugsson, Anais Malpica, Bent Fiane, Kjell I. Lovslett, Arnold-Jan Kruse, Irene Tveiteras Ovestad, Feja Voorhorst, Emiel A. M. Janssen, Jan P. A. Baak

*Corresponding author for this work

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Abstract

Objective: Cervical intraepithelial neoplasia grades 2-3 (CIN2-3) are usually treated by cone excision, although only 30% progress to cancer and 6-50% regress spontaneously. The aim of this study was to examine the influence of clinical factors like smoking habits, number of lifetime sexual partners, age at first sexual intercourse, sexual activity span and hormonal versus non-hormonal contraception type on the regression rate of CIN2-3. Methods: In this prospective population-based cohort study 170 women aged 25-40 with abnormal cytology and colposcopy-directed biopsies showing first time onset CIN2-3 were consecutively included. The interval between biopsy and cone excision was standardized to minimum 12 weeks. Regression was defined as
Original languageEnglish
Article numbere45114
JournalPLOS ONE
Volume7
Issue number9
DOIs
Publication statusPublished - 13 Sep 2012

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