Consistent Condom Use Increases the Regression Rate of Cervical Intraepithelial Neoplasia 2-3

Ane Cecilie Munk; Einar Gudlaugsson; Anais Malpica; Bent Fiane; Kjell I. Lovslett; Arnold-Jan Kruse; Irene Tveiteras Ovestad; Feja Voorhorst; Emiel A. M. Janssen; Jan P. A. Baak

doi:10.1371/journal.pone.0045114

Consistent Condom Use Increases the Regression Rate of Cervical Intraepithelial Neoplasia 2-3

Ane Cecilie Munk^*, Einar Gudlaugsson, Anais Malpica, Bent Fiane, Kjell I. Lovslett, Arnold-Jan Kruse, Irene Tveiteras Ovestad, Feja Voorhorst, Emiel A. M. Janssen, Jan P. A. Baak

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: Cervical intraepithelial neoplasia grades 2-3 (CIN2-3) are usually treated by cone excision, although only 30% progress to cancer and 6-50% regress spontaneously. The aim of this study was to examine the influence of clinical factors like smoking habits, number of lifetime sexual partners, age at first sexual intercourse, sexual activity span and hormonal versus non-hormonal contraception type on the regression rate of CIN2-3. Methods: In this prospective population-based cohort study 170 women aged 25-40 with abnormal cytology and colposcopy-directed biopsies showing first time onset CIN2-3 were consecutively included. The interval between biopsy and cone excision was standardized to minimum 12 weeks. Regression was defined as

Original language	English
Article number	e45114
Journal	PLOS ONE
Volume	7
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0045114
Publication status	Published - 13 Sept 2012

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10.1371/journal.pone.0045114Licence: CC BY

Cite this

@article{339a571e2326465e8ab7df95812cee28,

title = "Consistent Condom Use Increases the Regression Rate of Cervical Intraepithelial Neoplasia 2-3",

abstract = "Objective: Cervical intraepithelial neoplasia grades 2-3 (CIN2-3) are usually treated by cone excision, although only 30% progress to cancer and 6-50% regress spontaneously. The aim of this study was to examine the influence of clinical factors like smoking habits, number of lifetime sexual partners, age at first sexual intercourse, sexual activity span and hormonal versus non-hormonal contraception type on the regression rate of CIN2-3. Methods: In this prospective population-based cohort study 170 women aged 25-40 with abnormal cytology and colposcopy-directed biopsies showing first time onset CIN2-3 were consecutively included. The interval between biopsy and cone excision was standardized to minimum 12 weeks. Regression was defined as ",

author = "Munk, {Ane Cecilie} and Einar Gudlaugsson and Anais Malpica and Bent Fiane and Lovslett, {Kjell I.} and Arnold-Jan Kruse and Ovestad, {Irene Tveiteras} and Feja Voorhorst and Janssen, {Emiel A. M.} and Baak, {Jan P. A.}",

year = "2012",

month = sep,

day = "13",

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T1 - Consistent Condom Use Increases the Regression Rate of Cervical Intraepithelial Neoplasia 2-3

AU - Munk, Ane Cecilie

AU - Gudlaugsson, Einar

AU - Malpica, Anais

AU - Fiane, Bent

AU - Lovslett, Kjell I.

AU - Kruse, Arnold-Jan

AU - Ovestad, Irene Tveiteras

AU - Voorhorst, Feja

AU - Janssen, Emiel A. M.

AU - Baak, Jan P. A.

PY - 2012/9/13

Y1 - 2012/9/13

N2 - Objective: Cervical intraepithelial neoplasia grades 2-3 (CIN2-3) are usually treated by cone excision, although only 30% progress to cancer and 6-50% regress spontaneously. The aim of this study was to examine the influence of clinical factors like smoking habits, number of lifetime sexual partners, age at first sexual intercourse, sexual activity span and hormonal versus non-hormonal contraception type on the regression rate of CIN2-3. Methods: In this prospective population-based cohort study 170 women aged 25-40 with abnormal cytology and colposcopy-directed biopsies showing first time onset CIN2-3 were consecutively included. The interval between biopsy and cone excision was standardized to minimum 12 weeks. Regression was defined as

AB - Objective: Cervical intraepithelial neoplasia grades 2-3 (CIN2-3) are usually treated by cone excision, although only 30% progress to cancer and 6-50% regress spontaneously. The aim of this study was to examine the influence of clinical factors like smoking habits, number of lifetime sexual partners, age at first sexual intercourse, sexual activity span and hormonal versus non-hormonal contraception type on the regression rate of CIN2-3. Methods: In this prospective population-based cohort study 170 women aged 25-40 with abnormal cytology and colposcopy-directed biopsies showing first time onset CIN2-3 were consecutively included. The interval between biopsy and cone excision was standardized to minimum 12 weeks. Regression was defined as

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DO - 10.1371/journal.pone.0045114

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