Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Michele A La Merrill; Laura N Vandenberg; Martyn T Smith; William Goodson; Patience Browne; Heather B Patisaul; Kathryn Z Guyton; Andreas Kortenkamp; Vincent J Cogliano; Tracey J Woodruff; Linda Rieswijk; Hideko Sone; Kenneth S Korach; Andrea C Gore; Lauren Zeise; R Thomas Zoeller

doi:10.1038/s41574-019-0273-8

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Michele A La Merrill^*, Laura N Vandenberg, Martyn T Smith, William Goodson, Patience Browne, Heather B Patisaul, Kathryn Z Guyton, Andreas Kortenkamp, Vincent J Cogliano, Tracey J Woodruff, Linda Rieswijk, Hideko Sone, Kenneth S Korach, Andrea C Gore, Lauren Zeise, R Thomas Zoeller

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

191 Citations (Web of Science)

Abstract

Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.

Original language	English
Pages (from-to)	45-57
Number of pages	13
Journal	Nature Reviews Endocrinology
Volume	16
Issue number	1
Early online date	12 Nov 2019
DOIs	https://doi.org/10.1038/s41574-019-0273-8
Publication status	Published - Jan 2020

Keywords

BISPHENOL-A EXPOSURE
DEVELOPMENTAL EXPOSURE
DIETHYLSTILBESTROL DES
ENVIRONMENTAL ESTROGENS
ESTROGEN-RECEPTOR-ALPHA
GENE-EXPRESSION
HORMONE SYNTHESIS
IN-UTERO
PRENATAL EXPOSURE
SEXUAL-DIFFERENTIATION

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Cite this

La Merrill, M. A., Vandenberg, L. N., Smith, M. T., Goodson, W., Browne, P., Patisaul, H. B., Guyton, K. Z., Kortenkamp, A., Cogliano, V. J., Woodruff, T. J., Rieswijk, L., Sone, H., Korach, K. S., Gore, A. C., Zeise, L., & Zoeller, R. T. (2020). Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nature Reviews Endocrinology, 16(1), 45-57. https://doi.org/10.1038/s41574-019-0273-8

La Merrill, Michele A ; Vandenberg, Laura N ; Smith, Martyn T ; Goodson, William ; Browne, Patience ; Patisaul, Heather B ; Guyton, Kathryn Z ; Kortenkamp, Andreas ; Cogliano, Vincent J ; Woodruff, Tracey J ; Rieswijk, Linda ; Sone, Hideko ; Korach, Kenneth S ; Gore, Andrea C ; Zeise, Lauren ; Zoeller, R Thomas. / Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. In: Nature Reviews Endocrinology. 2020 ; Vol. 16, No. 1. pp. 45-57.

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abstract = "Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.",

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author = "{La Merrill}, {Michele A} and Vandenberg, {Laura N} and Smith, {Martyn T} and William Goodson and Patience Browne and Patisaul, {Heather B} and Guyton, {Kathryn Z} and Andreas Kortenkamp and Cogliano, {Vincent J} and Woodruff, {Tracey J} and Linda Rieswijk and Hideko Sone and Korach, {Kenneth S} and Gore, {Andrea C} and Lauren Zeise and Zoeller, {R Thomas}",

year = "2020",

month = jan,

doi = "10.1038/s41574-019-0273-8",

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La Merrill, MA, Vandenberg, LN, Smith, MT, Goodson, W, Browne, P, Patisaul, HB, Guyton, KZ, Kortenkamp, A, Cogliano, VJ, Woodruff, TJ, Rieswijk, L, Sone, H, Korach, KS, Gore, AC, Zeise, L & Zoeller, RT 2020, 'Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification', Nature Reviews Endocrinology, vol. 16, no. 1, pp. 45-57. https://doi.org/10.1038/s41574-019-0273-8

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. / La Merrill, Michele A; Vandenberg, Laura N; Smith, Martyn T; Goodson, William; Browne, Patience; Patisaul, Heather B; Guyton, Kathryn Z; Kortenkamp, Andreas; Cogliano, Vincent J; Woodruff, Tracey J; Rieswijk, Linda; Sone, Hideko; Korach, Kenneth S; Gore, Andrea C; Zeise, Lauren; Zoeller, R Thomas.

In: Nature Reviews Endocrinology, Vol. 16, No. 1, 01.2020, p. 45-57.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Patisaul, Heather B

AU - Guyton, Kathryn Z

AU - Kortenkamp, Andreas

AU - Cogliano, Vincent J

AU - Woodruff, Tracey J

AU - Rieswijk, Linda

AU - Sone, Hideko

AU - Korach, Kenneth S

AU - Gore, Andrea C

AU - Zeise, Lauren

AU - Zoeller, R Thomas

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KW - HORMONE SYNTHESIS

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KW - PRENATAL EXPOSURE

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