Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia

Michiel Kroesen; Hendrik T. Mulder; Jeanette M. L. van Holthe; Aleida A. Aangeenbrug; Jan Willem M. Mens; Helena C. van Doorn; Margarethus M. Paulides; Esther Oomen-de Hoop; Rene M. Vernhout; Ludy C. Lutgens; Gerard C. van Rhoon; Martine Franckena

doi:10.1016/j.radonc.2019.06.021

Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia

Michiel Kroesen, Hendrik T. Mulder, Jeanette M. L. van Holthe, Aleida A. Aangeenbrug, Jan Willem M. Mens, Helena C. van Doorn, Margarethus M. Paulides, Esther Oomen-de Hoop, Rene M. Vernhout, Ludy C. Lutgens, Gerard C. van Rhoon, Martine Franckena^*

^*Corresponding author for this work

GROW - Innovative Cancer Diagnostics & Therapy

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniques were introduced resulting in improved LC.

Aim: To validate the effect of thermal dose in a more recent cohort of patients treated with modern radiotherapy techniques, including image guided brachytherapy (IGBT).

Methods: We analyzed primary cervical carcinoma patients treated with a combination of radiotherapy and deep hyperthermia between 2005 and 2016 at our institute. Data on patient, tumor and treatment were collected including the thermal dose parameters TRISE and CEM43T90. Follow-up data on LC, disease free survival, DSS, OS as well as late toxicity data were collected. Data were analyzed using the Cox proportional hazard and Kaplan-Meier analyses.

Results: 227 patients were included. In multivariate analysis, histology, FIGO stage, lymphadenopathy, TRISE, CEM43T90 and IGBT had a significant effect on LC. In the patients treated with IGBT, the thermal dose parameter TRISE remained to have a significant effect on LC in univariate analysis.

Conclusions: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed. (C) 2019 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	150-158
Number of pages	9
Journal	Radiotherapy and Oncology
Volume	140
DOIs	https://doi.org/10.1016/j.radonc.2019.06.021
Publication status	Published - Nov 2019

Keywords

Hyperthermia
Cervical cancer
Treatment outcome
Thermal dose
Trise
CEM43T90
Image guided brachytherapy
GUIDED ADAPTIVE BRACHYTHERAPY
CLINICAL IMPLEMENTATION
REGIONAL HYPERTHERMIA
DEEP HYPERTHERMIA
RANDOMIZED-TRIAL
CANCER
RADIOTHERAPY
TIME
RADIOCHEMOTHERAPY
TEMPERATURE

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10.1016/j.radonc.2019.06.021

Cite this

Kroesen, M., Mulder, H. T., van Holthe, J. M. L., Aangeenbrug, A. A., Mens, J. W. M., van Doorn, H. C., Paulides, M. M., Oomen-de Hoop, E., Vernhout, R. M., Lutgens, L. C., van Rhoon, G. C., & Franckena, M. (2019). Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia. Radiotherapy and Oncology, 140, 150-158. https://doi.org/10.1016/j.radonc.2019.06.021

@article{5bd6a5e0972f46b0be47ea597e82a06a,

title = "Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia",

abstract = "Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniques were introduced resulting in improved LC.Aim: To validate the effect of thermal dose in a more recent cohort of patients treated with modern radiotherapy techniques, including image guided brachytherapy (IGBT).Methods: We analyzed primary cervical carcinoma patients treated with a combination of radiotherapy and deep hyperthermia between 2005 and 2016 at our institute. Data on patient, tumor and treatment were collected including the thermal dose parameters TRISE and CEM43T90. Follow-up data on LC, disease free survival, DSS, OS as well as late toxicity data were collected. Data were analyzed using the Cox proportional hazard and Kaplan-Meier analyses.Results: 227 patients were included. In multivariate analysis, histology, FIGO stage, lymphadenopathy, TRISE, CEM43T90 and IGBT had a significant effect on LC. In the patients treated with IGBT, the thermal dose parameter TRISE remained to have a significant effect on LC in univariate analysis.Conclusions: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed. (C) 2019 Elsevier B.V. All rights reserved.",

keywords = "Hyperthermia, Cervical cancer, Treatment outcome, Thermal dose, Trise, CEM43T90, Image guided brachytherapy, GUIDED ADAPTIVE BRACHYTHERAPY, CLINICAL IMPLEMENTATION, REGIONAL HYPERTHERMIA, DEEP HYPERTHERMIA, RANDOMIZED-TRIAL, CANCER, RADIOTHERAPY, TIME, RADIOCHEMOTHERAPY, TEMPERATURE",

author = "Michiel Kroesen and Mulder, {Hendrik T.} and {van Holthe}, {Jeanette M. L.} and Aangeenbrug, {Aleida A.} and Mens, {Jan Willem M.} and {van Doorn}, {Helena C.} and Paulides, {Margarethus M.} and {Oomen-de Hoop}, Esther and Vernhout, {Rene M.} and Lutgens, {Ludy C.} and {van Rhoon}, {Gerard C.} and Martine Franckena",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = nov,

doi = "10.1016/j.radonc.2019.06.021",

language = "English",

volume = "140",

pages = "150--158",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

}

Kroesen, M, Mulder, HT, van Holthe, JML, Aangeenbrug, AA, Mens, JWM, van Doorn, HC, Paulides, MM, Oomen-de Hoop, E, Vernhout, RM, Lutgens, LC, van Rhoon, GC & Franckena, M 2019, 'Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia', Radiotherapy and Oncology, vol. 140, pp. 150-158. https://doi.org/10.1016/j.radonc.2019.06.021

Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia. / Kroesen, Michiel; Mulder, Hendrik T.; van Holthe, Jeanette M. L. et al.
In: Radiotherapy and Oncology, Vol. 140, 11.2019, p. 150-158.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia

AU - Kroesen, Michiel

AU - Mulder, Hendrik T.

AU - van Holthe, Jeanette M. L.

AU - Aangeenbrug, Aleida A.

AU - Mens, Jan Willem M.

AU - van Doorn, Helena C.

AU - Paulides, Margarethus M.

AU - Oomen-de Hoop, Esther

AU - Vernhout, Rene M.

AU - Lutgens, Ludy C.

AU - van Rhoon, Gerard C.

AU - Franckena, Martine

PY - 2019/11

Y1 - 2019/11

N2 - Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniques were introduced resulting in improved LC.Aim: To validate the effect of thermal dose in a more recent cohort of patients treated with modern radiotherapy techniques, including image guided brachytherapy (IGBT).Methods: We analyzed primary cervical carcinoma patients treated with a combination of radiotherapy and deep hyperthermia between 2005 and 2016 at our institute. Data on patient, tumor and treatment were collected including the thermal dose parameters TRISE and CEM43T90. Follow-up data on LC, disease free survival, DSS, OS as well as late toxicity data were collected. Data were analyzed using the Cox proportional hazard and Kaplan-Meier analyses.Results: 227 patients were included. In multivariate analysis, histology, FIGO stage, lymphadenopathy, TRISE, CEM43T90 and IGBT had a significant effect on LC. In the patients treated with IGBT, the thermal dose parameter TRISE remained to have a significant effect on LC in univariate analysis.Conclusions: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed. (C) 2019 Elsevier B.V. All rights reserved.

AB - Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniques were introduced resulting in improved LC.Aim: To validate the effect of thermal dose in a more recent cohort of patients treated with modern radiotherapy techniques, including image guided brachytherapy (IGBT).Methods: We analyzed primary cervical carcinoma patients treated with a combination of radiotherapy and deep hyperthermia between 2005 and 2016 at our institute. Data on patient, tumor and treatment were collected including the thermal dose parameters TRISE and CEM43T90. Follow-up data on LC, disease free survival, DSS, OS as well as late toxicity data were collected. Data were analyzed using the Cox proportional hazard and Kaplan-Meier analyses.Results: 227 patients were included. In multivariate analysis, histology, FIGO stage, lymphadenopathy, TRISE, CEM43T90 and IGBT had a significant effect on LC. In the patients treated with IGBT, the thermal dose parameter TRISE remained to have a significant effect on LC in univariate analysis.Conclusions: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed. (C) 2019 Elsevier B.V. All rights reserved.

KW - Hyperthermia

KW - Cervical cancer

KW - Treatment outcome

KW - Thermal dose

KW - Trise

KW - CEM43T90

KW - Image guided brachytherapy

KW - GUIDED ADAPTIVE BRACHYTHERAPY

KW - CLINICAL IMPLEMENTATION

KW - REGIONAL HYPERTHERMIA

KW - DEEP HYPERTHERMIA

KW - RANDOMIZED-TRIAL

KW - CANCER

KW - RADIOTHERAPY

KW - TIME

KW - RADIOCHEMOTHERAPY

KW - TEMPERATURE

U2 - 10.1016/j.radonc.2019.06.021

DO - 10.1016/j.radonc.2019.06.021

M3 - Article

SN - 0167-8140

VL - 140

SP - 150

EP - 158

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -