Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes

Alberto A. Toffano; Giacomo Chiarot; Stefano Zamuner; Margherita Marchi; Erika Salvi; Stephen G. Waxman; Catharina G. Faber; Giuseppe Lauria; Achille Giacometti; Marta Simeoni

doi:10.1038/s41598-020-74591-y

Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes

Alberto A. Toffano, Giacomo Chiarot, Stefano Zamuner, Margherita Marchi, Erika Salvi, Stephen G. Waxman, Catharina G. Faber, Giuseppe Lauria, Achille Giacometti, Marta Simeoni^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	17930
Number of pages	17
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-74591-y
Publication status	Published - 21 Oct 2020

Keywords

GATED SODIUM-CHANNELS
NA(V)1.7 MUTATION
DISORDER MUTATIONS
SLOW-INACTIVATION
SCN9A MUTATIONS
ALPHA-SUBUNIT
ERYTHROMELALGIA
ERYTHERMALGIA
CARBAMAZEPINE
PREDICTION

Access to Document

10.1038/s41598-020-74591-yLicence: CC BY

Cite this

@article{4702693913b040599de2639453c8c3b8,

title = "Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes",

keywords = "GATED SODIUM-CHANNELS, NA(V)1.7 MUTATION, DISORDER MUTATIONS, SLOW-INACTIVATION, SCN9A MUTATIONS, ALPHA-SUBUNIT, ERYTHROMELALGIA, ERYTHERMALGIA, CARBAMAZEPINE, PREDICTION",

author = "Toffano, {Alberto A.} and Giacomo Chiarot and Stefano Zamuner and Margherita Marchi and Erika Salvi and Waxman, {Stephen G.} and Faber, {Catharina G.} and Giuseppe Lauria and Achille Giacometti and Marta Simeoni",

year = "2020",

month = oct,

day = "21",

doi = "10.1038/s41598-020-74591-y",

language = "English",

volume = "10",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes. / Toffano, Alberto A.; Chiarot, Giacomo; Zamuner, Stefano; Marchi, Margherita; Salvi, Erika; Waxman, Stephen G.; Faber, Catharina G.; Lauria, Giuseppe; Giacometti, Achille; Simeoni, Marta.

In: Scientific Reports, Vol. 10, No. 1, 17930, 21.10.2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes

AU - Toffano, Alberto A.

AU - Chiarot, Giacomo

AU - Zamuner, Stefano

AU - Marchi, Margherita

AU - Salvi, Erika

AU - Waxman, Stephen G.

AU - Faber, Catharina G.

AU - Lauria, Giuseppe

AU - Giacometti, Achille

AU - Simeoni, Marta

PY - 2020/10/21

Y1 - 2020/10/21

KW - GATED SODIUM-CHANNELS

KW - NA(V)1.7 MUTATION

KW - DISORDER MUTATIONS

KW - SLOW-INACTIVATION

KW - SCN9A MUTATIONS

KW - ALPHA-SUBUNIT

KW - ERYTHROMELALGIA

KW - ERYTHERMALGIA

KW - CARBAMAZEPINE

KW - PREDICTION

U2 - 10.1038/s41598-020-74591-y

DO - 10.1038/s41598-020-74591-y

M3 - Article

C2 - 33087732

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 17930

ER -