TY - JOUR
T1 - Computational modeling of bone fracture non-unions
T2 - four clinically relevant case studies
AU - Carlier, Aurélie
AU - Lammens, Johan
AU - Van Oosterwyck, Hans
AU - Geris, Liesbet
PY - 2015/12/29
Y1 - 2015/12/29
N2 - The human skeleton has a remarkable regeneration capacity. Nevertheless, 5-10 % of the bone fractures fails to heal and develops into a non-union which is a challenging orthopedic complication requiring complex and expensive treatment. This review paper will discuss four different computational models, each capturing a particular clinical case of non-union: non-union induced by reaming of the marrow canal and periosteal stripping, non-union due to a large interfragmentary gap, non-union due to a genetic disorder [i.e. NF1 related congenital pseudoarthrosis of the tibia (CPT)] and non-union due to mechanical overload. Together, the four computational models are able to capture the etiology of a wide range of fracture non-union types and design novel treatment strategies thereof. Further research is required to corroborate the computational models in both animal and human settings and translate them from bench to bed side.
AB - The human skeleton has a remarkable regeneration capacity. Nevertheless, 5-10 % of the bone fractures fails to heal and develops into a non-union which is a challenging orthopedic complication requiring complex and expensive treatment. This review paper will discuss four different computational models, each capturing a particular clinical case of non-union: non-union induced by reaming of the marrow canal and periosteal stripping, non-union due to a large interfragmentary gap, non-union due to a genetic disorder [i.e. NF1 related congenital pseudoarthrosis of the tibia (CPT)] and non-union due to mechanical overload. Together, the four computational models are able to capture the etiology of a wide range of fracture non-union types and design novel treatment strategies thereof. Further research is required to corroborate the computational models in both animal and human settings and translate them from bench to bed side.
KW - Review
KW - Journal Article
U2 - 10.1186/s40482-015-0004-x
DO - 10.1186/s40482-015-0004-x
M3 - (Systematic) Review article
C2 - 26709368
SN - 2196-050X
VL - 2
SP - 1
JO - In Silico Cell and Tissue Science
JF - In Silico Cell and Tissue Science
ER -