Computational model for estimating the short- and long-term cardiac response to arteriovenous fistula creation for hemodialysis

Wilco Kroon*, Marielle Bosboom, Wouter Huberts, Jan Tordoir, Frans van de Vosse

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Creation of an arteriovenous fistula (AVF) for hemodialysis may result in cardiac failure due to dramatic increases in cardiac output. To investigate the quantitative relations between AVF flow, changes in cardiac output, myocardial stress and strain and resulting left ventricular adaptation, a computational model is developed. The model combines a one-dimensional pulse wave propagation model of the arterial network with a zero-dimensional one-fiber model of cardiac mechanics and includes adaptation rules to capture the effect of the baro-reflex and long-term structural remodelling of the left ventricle. Using generic vascular and cardiac parameters based on literature, simulations are done that illustrate the model's ability to quantitatively reproduce the clinically observed increase in brachial flow and cardiac output as well as occurence of eccentric hypertrophy. Patient-specific clinical data is needed to investigate the value of the computational model for personalized predictions.
Original languageEnglish
Pages (from-to)1289-1298
JournalMedical & Biological Engineering & Computing
Issue number12
Publication statusPublished - Dec 2012


  • Vascular access
  • Cardiac mechanics
  • Ventricular remodeling
  • Adaptation
  • Heart failure

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