Comprehensive autophagy evaluation in cardiac disease models

Nina Kaludercic; Maria Chiara Maiuri; Susmita Kaushik; Alvaro F. Fernandez; Jenny de Bruijn; Francesca Castoldi; Yun Chen; Jumpei Ito; Risa Mukai; Tomokazu Murakawa; Jihoon Nah; Federico Pietrocola; Toshiro Saito; Salwa Sebti; Martina Semenzato; Lorenza Tsansizi; Sebastiano Sciarretta; Julio Madrigal-Matute; Leducq Transatlantic Network on Modulating Autophagy to Treat CV Disease

doi:10.1093/cvr/cvz233

Comprehensive autophagy evaluation in cardiac disease models

Nina Kaludercic, Maria Chiara Maiuri, Susmita Kaushik, Alvaro F. Fernandez, Jenny de Bruijn, Francesca Castoldi, Yun Chen, Jumpei Ito, Risa Mukai, Tomokazu Murakawa, Jihoon Nah, Federico Pietrocola, Toshiro Saito, Salwa Sebti, Martina Semenzato, Lorenza Tsansizi, Sebastiano Sciarretta^*, Julio Madrigal-Matute^*, Leducq Transatlantic Network on Modulating Autophagy to Treat CV Disease

^*Corresponding author for this work

Carim - The vulnerable plaque: makers and markers

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

Original language	English
Pages (from-to)	483-504
Number of pages	22
Journal	Cardiovascular Research
Volume	116
Issue number	3
DOIs	https://doi.org/10.1093/cvr/cvz233
Publication status	Published - 1 Mar 2020

Keywords

Autophagy
Heart
Chaperone-mediated autophagy
Autosis
Mitophagy
Cardiac diseases
CHAPERONE-MEDIATED AUTOPHAGY
CALORIC RESTRICTION MIMETICS
ACTIVATED PROTEIN-KINASE
CELL-DEATH
MITOCHONDRIAL AUTOPHAGY
MOLECULAR-MECHANISMS
MYOCARDIAL AUTOPHAGY
FLUX
MITOPHAGY
MOUSE

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10.1093/cvr/cvz233Licence: CC BY-NC

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Kaludercic, N., Maiuri, M. C., Kaushik, S., Fernandez, A. F., de Bruijn, J., Castoldi, F., Chen, Y., Ito, J., Mukai, R., Murakawa, T., Nah, J., Pietrocola, F., Saito, T., Sebti, S., Semenzato, M., Tsansizi, L., Sciarretta, S., Madrigal-Matute, J., & Leducq Transatlantic Network on Modulating Autophagy to Treat CV Disease (2020). Comprehensive autophagy evaluation in cardiac disease models. Cardiovascular Research, 116(3), 483-504. https://doi.org/10.1093/cvr/cvz233

@article{8e59b3799159407293a793ffb2245dec,

title = "Comprehensive autophagy evaluation in cardiac disease models",

abstract = "Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.",

keywords = "Autophagy, Heart, Chaperone-mediated autophagy, Autosis, Mitophagy, Cardiac diseases, CHAPERONE-MEDIATED AUTOPHAGY, CALORIC RESTRICTION MIMETICS, ACTIVATED PROTEIN-KINASE, CELL-DEATH, MITOCHONDRIAL AUTOPHAGY, MOLECULAR-MECHANISMS, MYOCARDIAL AUTOPHAGY, FLUX, MITOPHAGY, MOUSE",

author = "Nina Kaludercic and Maiuri, {Maria Chiara} and Susmita Kaushik and Fernandez, {Alvaro F.} and {de Bruijn}, Jenny and Francesca Castoldi and Yun Chen and Jumpei Ito and Risa Mukai and Tomokazu Murakawa and Jihoon Nah and Federico Pietrocola and Toshiro Saito and Salwa Sebti and Martina Semenzato and Lorenza Tsansizi and Sebastiano Sciarretta and Julio Madrigal-Matute and {Leducq Transatlantic Network on Modulating Autophagy to Treat CV Disease}",

note = "Funding Information: This work was supported by the Fondation Leducq Transatlantic Network of Excellence [15CVD04]; the American Heart Association [17POST33650088 to J.M.M., 18POST34050036 to J.N., and 18POST34060247 to R.M.]; and the Italian Ministry of Health [GR-2013-02355401 to S.S.12,13]. Publisher Copyright: {\textcopyright} 2019 Published on behalf of the European Society of Cardiology. All rights reserved.",

year = "2020",

month = mar,

day = "1",

doi = "10.1093/cvr/cvz233",

language = "English",

volume = "116",

pages = "483--504",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "3",

}

Kaludercic, N, Maiuri, MC, Kaushik, S, Fernandez, AF, de Bruijn, J, Castoldi, F, Chen, Y, Ito, J, Mukai, R, Murakawa, T, Nah, J, Pietrocola, F, Saito, T, Sebti, S, Semenzato, M, Tsansizi, L, Sciarretta, S, Madrigal-Matute, J & Leducq Transatlantic Network on Modulating Autophagy to Treat CV Disease 2020, 'Comprehensive autophagy evaluation in cardiac disease models', Cardiovascular Research, vol. 116, no. 3, pp. 483-504. https://doi.org/10.1093/cvr/cvz233

TY - JOUR

T1 - Comprehensive autophagy evaluation in cardiac disease models

AU - Kaludercic, Nina

AU - Maiuri, Maria Chiara

AU - Kaushik, Susmita

AU - Fernandez, Alvaro F.

AU - de Bruijn, Jenny

AU - Castoldi, Francesca

AU - Chen, Yun

AU - Ito, Jumpei

AU - Mukai, Risa

AU - Murakawa, Tomokazu

AU - Nah, Jihoon

AU - Pietrocola, Federico

AU - Saito, Toshiro

AU - Sebti, Salwa

AU - Semenzato, Martina

AU - Tsansizi, Lorenza

AU - Sciarretta, Sebastiano

AU - Madrigal-Matute, Julio

AU - Leducq Transatlantic Network on Modulating Autophagy to Treat CV Disease

N1 - Funding Information: This work was supported by the Fondation Leducq Transatlantic Network of Excellence [15CVD04]; the American Heart Association [17POST33650088 to J.M.M., 18POST34050036 to J.N., and 18POST34060247 to R.M.]; and the Italian Ministry of Health [GR-2013-02355401 to S.S.12,13]. Publisher Copyright: © 2019 Published on behalf of the European Society of Cardiology. All rights reserved.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

AB - Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

KW - Autophagy

KW - Heart

KW - Chaperone-mediated autophagy

KW - Autosis

KW - Mitophagy

KW - Cardiac diseases

KW - CHAPERONE-MEDIATED AUTOPHAGY

KW - CALORIC RESTRICTION MIMETICS

KW - ACTIVATED PROTEIN-KINASE

KW - CELL-DEATH

KW - MITOCHONDRIAL AUTOPHAGY

KW - MOLECULAR-MECHANISMS

KW - MYOCARDIAL AUTOPHAGY

KW - FLUX

KW - MITOPHAGY

KW - MOUSE

U2 - 10.1093/cvr/cvz233

DO - 10.1093/cvr/cvz233

M3 - (Systematic) Review article

C2 - 31504266

SN - 0008-6363

VL - 116

SP - 483

EP - 504

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -

Comprehensive autophagy evaluation in cardiac disease models

Abstract

Keywords

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