TY - JOUR
T1 - Comprehensive autophagy evaluation in cardiac disease models
AU - Kaludercic, Nina
AU - Maiuri, Maria Chiara
AU - Kaushik, Susmita
AU - Fernandez, Alvaro F.
AU - de Bruijn, Jenny
AU - Castoldi, Francesca
AU - Chen, Yun
AU - Ito, Jumpei
AU - Mukai, Risa
AU - Murakawa, Tomokazu
AU - Nah, Jihoon
AU - Pietrocola, Federico
AU - Saito, Toshiro
AU - Sebti, Salwa
AU - Semenzato, Martina
AU - Tsansizi, Lorenza
AU - Sciarretta, Sebastiano
AU - Madrigal-Matute, Julio
AU - Leducq Transatlantic Network on Modulating Autophagy to Treat CV Disease
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.
AB - Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.
KW - Autophagy
KW - Heart
KW - Chaperone-mediated autophagy
KW - Autosis
KW - Mitophagy
KW - Cardiac diseases
KW - CHAPERONE-MEDIATED AUTOPHAGY
KW - CALORIC RESTRICTION MIMETICS
KW - ACTIVATED PROTEIN-KINASE
KW - CELL-DEATH
KW - MITOCHONDRIAL AUTOPHAGY
KW - MOLECULAR-MECHANISMS
KW - MYOCARDIAL AUTOPHAGY
KW - FLUX
KW - MITOPHAGY
KW - MOUSE
U2 - 10.1093/cvr/cvz233
DO - 10.1093/cvr/cvz233
M3 - (Systematic) Review article
C2 - 31504266
VL - 116
SP - 483
EP - 504
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 3
ER -