Comprehensive autophagy evaluation in cardiac disease models

Nina Kaludercic, Maria Chiara Maiuri, Susmita Kaushik, Alvaro F. Fernandez, Jenny de Bruijn, Francesca Castoldi, Yun Chen, Jumpei Ito, Risa Mukai, Tomokazu Murakawa, Jihoon Nah, Federico Pietrocola, Toshiro Saito, Salwa Sebti, Martina Semenzato, Lorenza Tsansizi, Sebastiano Sciarretta*, Julio Madrigal-Matute*, Leducq Transatlantic Network on Modulating Autophagy to Treat CV Disease

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

32 Citations (Web of Science)

Abstract

Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

Original languageEnglish
Pages (from-to)483-504
Number of pages22
JournalCardiovascular Research
Volume116
Issue number3
DOIs
Publication statusPublished - 1 Mar 2020

Keywords

  • Autophagy
  • Heart
  • Chaperone-mediated autophagy
  • Autosis
  • Mitophagy
  • Cardiac diseases
  • CHAPERONE-MEDIATED AUTOPHAGY
  • CALORIC RESTRICTION MIMETICS
  • ACTIVATED PROTEIN-KINASE
  • CELL-DEATH
  • MITOCHONDRIAL AUTOPHAGY
  • MOLECULAR-MECHANISMS
  • MYOCARDIAL AUTOPHAGY
  • FLUX
  • MITOPHAGY
  • MOUSE

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