Comprehensive analysis of pulmonary Large Cell Neuroendocrine Carcinoma (LCNEC): new insights to guide diagnosis and treatment

Jules Louis Derks

doi:10.26481/dis.20171208jd

Comprehensive analysis of pulmonary Large Cell Neuroendocrine Carcinoma (LCNEC): new insights to guide diagnosis and treatment

Jules Louis Derks

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

Neuroendocrine tumours in the lungs such as large-cell neuroendocrine carcinoma (LCNEC) are a rare occurrence in the Netherlands. Pathologists, oncologists and lung cancer oncologists are all confronted with various problems regarding the diagnosis and treatment of LCNEC. Firstly, making the diagnosis is difficult due to the lack of standards for small biopsies. Secondly, there is no clear advice regarding systemic treatment of patients with metastatic LCNEC. Based on these problems, this thesis studied temporary adjustments to the diagnosis and treatment of LCNEC in approximately 1,000 patients in the Netherlands. The accuracy of the diagnosis was checked by performing a biopsy. Finally, we examined which type of chemotherapy may result in better survival rates in patients with LCNEC undergoing treatment in primary care settings.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Dingemans, A-M.C., Supervisor Speel, Ernst, Supervisor
Award date	8 Dec 2017
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789462337633
DOIs	https://doi.org/10.26481/dis.20171208jd
Publication status	Published - 2017

Keywords

Large-cell Neuroendocrine Carcinoma (LCNEC)
diagnosis
treatment

Access to Document

10.26481/dis.20171208jd

Full textFinal published version, 28.7 MB
CoverFinal published version, 42.1 KB
AbstractFinal published version, 170 KB
PropositionsFinal published version, 317 KB
ValorisationFinal published version, 121 KB

Cite this

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title = "Comprehensive analysis of pulmonary Large Cell Neuroendocrine Carcinoma (LCNEC): new insights to guide diagnosis and treatment",

abstract = "Neuroendocrine tumours in the lungs such as large-cell neuroendocrine carcinoma (LCNEC) are a rare occurrence in the Netherlands. Pathologists, oncologists and lung cancer oncologists are all confronted with various problems regarding the diagnosis and treatment of LCNEC. Firstly, making the diagnosis is difficult due to the lack of standards for small biopsies. Secondly, there is no clear advice regarding systemic treatment of patients with metastatic LCNEC. Based on these problems, this thesis studied temporary adjustments to the diagnosis and treatment of LCNEC in approximately 1,000 patients in the Netherlands. The accuracy of the diagnosis was checked by performing a biopsy. Finally, we examined which type of chemotherapy may result in better survival rates in patients with LCNEC undergoing treatment in primary care settings.",

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AB - Neuroendocrine tumours in the lungs such as large-cell neuroendocrine carcinoma (LCNEC) are a rare occurrence in the Netherlands. Pathologists, oncologists and lung cancer oncologists are all confronted with various problems regarding the diagnosis and treatment of LCNEC. Firstly, making the diagnosis is difficult due to the lack of standards for small biopsies. Secondly, there is no clear advice regarding systemic treatment of patients with metastatic LCNEC. Based on these problems, this thesis studied temporary adjustments to the diagnosis and treatment of LCNEC in approximately 1,000 patients in the Netherlands. The accuracy of the diagnosis was checked by performing a biopsy. Finally, we examined which type of chemotherapy may result in better survival rates in patients with LCNEC undergoing treatment in primary care settings.

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