Complications in pulmonary vein isolation in the Netherlands Heart Registration differ with sex and ablation technique

D. Mol*, S. Houterman, J.C. Balt, R.E. Bhagwandien, Y. Blaauw, P.P.H. Delnoy, V.J. van Driel, A.H. Driessen, R.J. Folkeringa, R.J. Hassink, B.H. van Huysduynen, J.G. Luermans, A.J. Ouss, Y.J. Stevenhagen, D. van Veghel, S.W. Westra, J.S. de Jong, J.R. de Groot, Netherlands Heart Registration Ablation Registration Committee

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aims Pulmonary vein isolation (PVI) has become a cornerstone of the invasive treatment of atrial fibrillation. Severe complications are reported in 1-3% of patients. This study aims to compare complications and follow-up outcome of PVI in patients with atrial fibrillation.

Methods and results The data were extracted from the Netherlands Heart Registration. Procedural and follow-up outcomes in patients treated with conventional radiofrequency (C-RF), multielectrode phased RF (Ph-RF), or cryoballoon (CB) ablation from 2012 to 2017 were compared. Subgroup analysis was performed to identify variables associated with complications and repeat ablations. In total, 13 823 patients (69% male) were included. The reported complication incidence was 3.6%. Patients treated with C-RF developed more cardiac tamponades (C-RF 0.8% vs. Ph-RF 0.3% vs. CB 0.3%, P

Conclusion The reported complication rate during PVI was low. Patients treated with C-RF ablation were more likely to develop cardiac tamponades and vascular complications. Female sex was associated with more cardiac tamponade and bleeding complications.

Original languageEnglish
Pages (from-to)216-225
Number of pages10
JournalEP Europace
Issue number2
Publication statusPublished - 1 Feb 2021


  • Atrial fibrillation
  • Pulmonary vein isolation
  • Conventional radiofrequency ablation
  • Multielectrode phased radiofrequency ablation
  • Cryoballoon


Dive into the research topics of 'Complications in pulmonary vein isolation in the Netherlands Heart Registration differ with sex and ablation technique'. Together they form a unique fingerprint.

Cite this