Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Antoine Bondue*, Eloisa Arbustini, Anna Bianco, Michele Ciccarelli, Dana Dawson, Matteo De Rosa, Nazha Hamdani, Denise Hilfiker-Kleiner, Benjamin Meder, Adelino F. Leite-Moreira, Thomas Thum, Carlo G. Tocchetti, Gilda Varricchi, Jolanda Van der Velden, Roddy Walsh, Stephane Heymans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Web of Science)

Abstract

Dilated cardiomyopathy (DCM) frequently affects relatively young, economically, and socially active adults, and is an important cause of heart failure and transplantation. DCM is a complex disease and its pathological architecture encounters many genetic determinants interacting with environmental factors. The old perspective that every pathogenic gene mutation would lead to a diseased heart, is now being replaced by the novel observation that the phenotype depends not only on the penetrance-malignancy of the mutated gene-but also on epigenetics, age, toxic factors, pregnancy, and a diversity of acquired diseases. This review discusses how gene mutations will result in mutation-specific molecular alterations in the heart including increased mitochondrial oxidation (sarcomeric gene e.g. TTN), decreased calcium sensitivity (sarcomeric genes), fibrosis (e.g. LMNA and TTN), or inflammation. Therefore, getting a complete picture of the DCM patient will include genomic data, molecular assessment by preference from cardiac samples, stratification according to co-morbidities, and phenotypic description. Those data will help to better guide the heart failure and anti-arrhythmic treatment, predict response to therapy, develop novel siRNA-based gene silencing for malignant gene mutations, or intervene with mutation-specific altered gene pathways in the heart.
Original languageEnglish
Pages (from-to)1287-1303
Number of pages17
JournalCardiovascular Research
Volume114
Issue number10
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Dilated Cardiomyopathy
  • Genetics
  • Genome-environment interaction
  • ANTHRACYCLINE-INDUCED CARDIOTOXICITY
  • GENOME-WIDE ASSOCIATION
  • DOXORUBICIN-INDUCED CARDIOMYOPATHY
  • RIGHT-VENTRICULAR CARDIOMYOPATHY
  • CONGESTIVE-HEART-FAILURE
  • MYOSIN HEAVY-CHAIN
  • A/C GENE-MUTATIONS
  • MOGE(S) CLASSIFICATION
  • HYPERTROPHIC CARDIOMYOPATHY
  • PERIPARTUM CARDIOMYOPATHY

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