Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease: Results from the MOPEAD project

M. Boada; A. Rodrigo; F. Jessen; B. Wimblad; M. Kramberger; P.J. Visser; R. Simo; O. Rodriguez-Gomez; A. Ciudin; J. Georges; A. Dumas; P. Maguire; D. Krivec; A. Wimo; S. Valero; M. Alegret; L. Jamilis; M. Zwan; L. Sannemann; J. Arrufat; E. Stomrud; G. Johansson; C. Shering; B. Glaysher; N. Stewart; M. Belger; F. Iradier; L. Campo; MOPEAD Consortium

doi:10.1002/alz.12441

Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease: Results from the MOPEAD project

M. Boada^*, A. Rodrigo, F. Jessen, B. Wimblad, M. Kramberger, P.J. Visser, R. Simo, O. Rodriguez-Gomez, A. Ciudin, J. Georges, A. Dumas, P. Maguire, D. Krivec, A. Wimo, S. Valero, M. Alegret, L. Jamilis, M. Zwan, L. Sannemann, J. ArrufatE. Stomrud, G. Johansson, C. Shering, B. Glaysher, N. Stewart, M. Belger, F. Iradier, L. Campo, MOPEAD Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Methods Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care-based protocol for early detection of cognitive decline (PC), and (4) a tertiary care-based pre-screening at diabetologist clinics (DC). Results A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39.7%). The corresponding proportion for the different initiatives were 36.8% (WB), 35.6% (OHI), 44.4% (PC), and 58.3% (DC). Conclusion These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.

Original language	English
Pages (from-to)	1119-1127
Number of pages	9
Journal	Alzheimer's & Dementia
Volume	18
Issue number	6
Early online date	26 Jul 2021
DOIs	https://doi.org/10.1002/alz.12441
Publication status	Published - Jun 2022

Keywords

Alzheimer's disease
diagnostic gap
early diagnosis
patient engagement
population-based screening
MINI-MENTAL STATE
RECRUITMENT METHODS
DEMENTIA
PREDICTION
RISK

Access to Document

10.1002/alz.12441Licence: CC BY-NC

Cite this

Boada, M., Rodrigo, A., Jessen, F., Wimblad, B., Kramberger, M., Visser, P. J., Simo, R., Rodriguez-Gomez, O., Ciudin, A., Georges, J., Dumas, A., Maguire, P., Krivec, D., Wimo, A., Valero, S., Alegret, M., Jamilis, L., Zwan, M., Sannemann, L., ... MOPEAD Consortium (2022). Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease: Results from the MOPEAD project. Alzheimer's & Dementia, 18(6), 1119-1127. https://doi.org/10.1002/alz.12441

@article{bd16279b52a34b64b6a959ffcb5c3c3d,

title = "Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease: Results from the MOPEAD project",

abstract = "Introduction The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Methods Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care-based protocol for early detection of cognitive decline (PC), and (4) a tertiary care-based pre-screening at diabetologist clinics (DC). Results A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39.7%). The corresponding proportion for the different initiatives were 36.8% (WB), 35.6% (OHI), 44.4% (PC), and 58.3% (DC). Conclusion These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.",

keywords = "Alzheimer's disease, diagnostic gap, early diagnosis, patient engagement, population-based screening, MINI-MENTAL STATE, RECRUITMENT METHODS, DEMENTIA, PREDICTION, RISK",

author = "M. Boada and A. Rodrigo and F. Jessen and B. Wimblad and M. Kramberger and P.J. Visser and R. Simo and O. Rodriguez-Gomez and A. Ciudin and J. Georges and A. Dumas and P. Maguire and D. Krivec and A. Wimo and S. Valero and M. Alegret and L. Jamilis and M. Zwan and L. Sannemann and J. Arrufat and E. Stomrud and G. Johansson and C. Shering and B. Glaysher and N. Stewart and M. Belger and F. Iradier and L. Campo and {MOPEAD Consortium}",

year = "2022",

month = jun,

doi = "10.1002/alz.12441",

language = "English",

volume = "18",

pages = "1119--1127",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier Science",

number = "6",

}

Boada, M, Rodrigo, A, Jessen, F, Wimblad, B, Kramberger, M, Visser, PJ, Simo, R, Rodriguez-Gomez, O, Ciudin, A, Georges, J, Dumas, A, Maguire, P, Krivec, D, Wimo, A, Valero, S, Alegret, M, Jamilis, L, Zwan, M, Sannemann, L, Arrufat, J, Stomrud, E, Johansson, G, Shering, C, Glaysher, B, Stewart, N, Belger, M, Iradier, F, Campo, L & MOPEAD Consortium 2022, 'Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease: Results from the MOPEAD project', Alzheimer's & Dementia, vol. 18, no. 6, pp. 1119-1127. https://doi.org/10.1002/alz.12441

TY - JOUR

T1 - Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease: Results from the MOPEAD project

AU - Boada, M.

AU - Rodrigo, A.

AU - Jessen, F.

AU - Wimblad, B.

AU - Kramberger, M.

AU - Visser, P.J.

AU - Simo, R.

AU - Rodriguez-Gomez, O.

AU - Ciudin, A.

AU - Georges, J.

AU - Dumas, A.

AU - Maguire, P.

AU - Krivec, D.

AU - Wimo, A.

AU - Valero, S.

AU - Alegret, M.

AU - Jamilis, L.

AU - Zwan, M.

AU - Sannemann, L.

AU - Arrufat, J.

AU - Stomrud, E.

AU - Johansson, G.

AU - Shering, C.

AU - Glaysher, B.

AU - Stewart, N.

AU - Belger, M.

AU - Iradier, F.

AU - Campo, L.

AU - MOPEAD Consortium

PY - 2022/6

Y1 - 2022/6

N2 - Introduction The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Methods Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care-based protocol for early detection of cognitive decline (PC), and (4) a tertiary care-based pre-screening at diabetologist clinics (DC). Results A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39.7%). The corresponding proportion for the different initiatives were 36.8% (WB), 35.6% (OHI), 44.4% (PC), and 58.3% (DC). Conclusion These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.

AB - Introduction The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Methods Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care-based protocol for early detection of cognitive decline (PC), and (4) a tertiary care-based pre-screening at diabetologist clinics (DC). Results A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39.7%). The corresponding proportion for the different initiatives were 36.8% (WB), 35.6% (OHI), 44.4% (PC), and 58.3% (DC). Conclusion These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.

KW - Alzheimer's disease

KW - diagnostic gap

KW - early diagnosis

KW - patient engagement

KW - population-based screening

KW - MINI-MENTAL STATE

KW - RECRUITMENT METHODS

KW - DEMENTIA

KW - PREDICTION

KW - RISK

U2 - 10.1002/alz.12441

DO - 10.1002/alz.12441

M3 - Article

C2 - 34310061

SN - 1552-5260

VL - 18

SP - 1119

EP - 1127

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 6

ER -