Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome

Monique Engel*, Relana M. E. Nowacki, Lucy K. Reiss, Stefan Uhlig, Coen H. M. P. Willems, Nico Kloosterboer, J. Freek van Iwaarden, Alide C. P. Sewing, Matthias Seehase, Verena A. C. Lambermont, Jennifer J. P. Collins, Luc J. I. Zimmermann, Gijs D. Vos, Boris W. Kramer

*Corresponding author for this work

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Abstract

Recruitment manoeuvres are widely used in clinical practice to open the lung and prevent lung injury by derecruitment, although the evidence is still discussed. In this study two different recruitment manoeuvres were compared to no recruitment manoeuvres (control) in ventilated sheep with acute respiratory distress syndrome (ARDS), induced by lung lavage. We performed a prospective, randomised study in 26 ventilated sheep with ARDS, to evaluate the effect of two different recruitment manoeuvres on gas exchange, blood pressure and lung injury. The two different recruitment manoeuvres, the high pressure recruitment manoeuvre (HPRM), with high peak pressure, and the smooth and moderate recruitment manoeuvre (SMRM), with lower peak pressure, were compared to controls (no recruitment) after disconnection. Oxygenation index and ventilation efficacy index were calculated to evaluate gas exchange. Lung injury was assessed by inflammatory response in broncho-alveolar lavage fluid (BALF) and blood and histology of the lung. Oxygenation index improved significantly after both recruitment manoeuvres compared with controls, but no significant difference was found between the recruitment manoeuvres. Blood pressure decreased after HPRM but not after SMRM. HPRM induced a higher number of total cells and more neutrophils in the BALF. In the histology of the lung, mean alveolar size was increased in the dorsocranial region of the lung of SMRM compared to controls. Recruitment manoeuvres improved oxygenation, but SMRM was superior, with respect to hemodynamics and pulmonary inflammation, in ventilated sheep suffering from ARDS induced by lung lavage.
Original languageEnglish
Pages (from-to)77-86
JournalLung
Volume191
Issue number1
DOIs
Publication statusPublished - Feb 2013

Keywords

  • ARDS
  • Recruitment manoeuvres
  • Lung injury
  • Mechanical ventilation
  • Blood pressure

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