Comparison of postprandial oleic acid, 9c,11t CLA and 10t,12c CLA oxidation in healthy moderately overweight subjects

C. Malpuech Brugere; R.P. Mensink; O. Loreau; A. Maret; C.E. Fernie; T.S. Lassel; J.M. Chardigny; C.M. Scrimgeour; J.L. Sebedio; B. Beaufrere

doi:10.1007/s11745-010-3480-6

Comparison of postprandial oleic acid, 9c,11t CLA and 10t,12c CLA oxidation in healthy moderately overweight subjects

C. Malpuech Brugere, R.P. Mensink, O. Loreau, A. Maret, C.E. Fernie, T.S. Lassel, J.M. Chardigny^*, C.M. Scrimgeour, J.L. Sebedio, B. Beaufrere

^*Corresponding author for this work

Humane Biologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Few studies report the individual effect of 9c,11t- and 10t,12c-CLA on human energy metabolism. We compared the postprandial oxidative metabolism of 9c,11t- and 10t,12c-CLA and oleic acid (9c-18:1) in 22 healthy moderately overweight volunteers. After 24 weeks supplementation with 9c,11t-, 10t,12c-CLA or 9c-18:1 (3 g/day), subjects consumed a single oral bolus of the appropriate [1-(13)C]-labeled fatty acid. 8 h post-dose, cumulative oxidation was similar for 9c-18:1 and 10t,12c (P = 0.66), but significantly higher for 9c,11t (P < 0.01).

Original language	English
Pages (from-to)	1047-1051
Number of pages	5
Journal	Lipids
Volume	45
Issue number	11
DOIs	https://doi.org/10.1007/s11745-010-3480-6
Publication status	Published - Nov 2010

Keywords

Human
(CO2)-C-13
Oxidation
Conjugated linoleic acid
CONJUGATED LINOLEIC-ACID
BODY-FAT ACCUMULATION
ENERGY-METABOLISM
SUPPLEMENTATION
ISOMERS

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10.1007/s11745-010-3480-6

Cite this

@article{620ea05dc68e413c9d98bf059c5d23da,

title = "Comparison of postprandial oleic acid, 9c,11t CLA and 10t,12c CLA oxidation in healthy moderately overweight subjects",

abstract = "Few studies report the individual effect of 9c,11t- and 10t,12c-CLA on human energy metabolism. We compared the postprandial oxidative metabolism of 9c,11t- and 10t,12c-CLA and oleic acid (9c-18:1) in 22 healthy moderately overweight volunteers. After 24 weeks supplementation with 9c,11t-, 10t,12c-CLA or 9c-18:1 (3 g/day), subjects consumed a single oral bolus of the appropriate [1-(13)C]-labeled fatty acid. 8 h post-dose, cumulative oxidation was similar for 9c-18:1 and 10t,12c (P = 0.66), but significantly higher for 9c,11t (P < 0.01).",

keywords = "Human, (CO2)-C-13, Oxidation, Conjugated linoleic acid, CONJUGATED LINOLEIC-ACID, BODY-FAT ACCUMULATION, ENERGY-METABOLISM, SUPPLEMENTATION, ISOMERS",

author = "{Malpuech Brugere}, C. and R.P. Mensink and O. Loreau and A. Maret and C.E. Fernie and T.S. Lassel and J.M. Chardigny and C.M. Scrimgeour and J.L. Sebedio and B. Beaufrere",

year = "2010",

month = nov,

doi = "10.1007/s11745-010-3480-6",

language = "English",

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T1 - Comparison of postprandial oleic acid, 9c,11t CLA and 10t,12c CLA oxidation in healthy moderately overweight subjects

AU - Malpuech Brugere, C.

AU - Mensink, R.P.

AU - Loreau, O.

AU - Maret, A.

AU - Fernie, C.E.

AU - Lassel, T.S.

AU - Chardigny, J.M.

AU - Scrimgeour, C.M.

AU - Sebedio, J.L.

AU - Beaufrere, B.

PY - 2010/11

Y1 - 2010/11

N2 - Few studies report the individual effect of 9c,11t- and 10t,12c-CLA on human energy metabolism. We compared the postprandial oxidative metabolism of 9c,11t- and 10t,12c-CLA and oleic acid (9c-18:1) in 22 healthy moderately overweight volunteers. After 24 weeks supplementation with 9c,11t-, 10t,12c-CLA or 9c-18:1 (3 g/day), subjects consumed a single oral bolus of the appropriate [1-(13)C]-labeled fatty acid. 8 h post-dose, cumulative oxidation was similar for 9c-18:1 and 10t,12c (P = 0.66), but significantly higher for 9c,11t (P < 0.01).

AB - Few studies report the individual effect of 9c,11t- and 10t,12c-CLA on human energy metabolism. We compared the postprandial oxidative metabolism of 9c,11t- and 10t,12c-CLA and oleic acid (9c-18:1) in 22 healthy moderately overweight volunteers. After 24 weeks supplementation with 9c,11t-, 10t,12c-CLA or 9c-18:1 (3 g/day), subjects consumed a single oral bolus of the appropriate [1-(13)C]-labeled fatty acid. 8 h post-dose, cumulative oxidation was similar for 9c-18:1 and 10t,12c (P = 0.66), but significantly higher for 9c,11t (P < 0.01).

KW - Human

KW - (CO2)-C-13

KW - Oxidation

KW - Conjugated linoleic acid

KW - CONJUGATED LINOLEIC-ACID

KW - BODY-FAT ACCUMULATION

KW - ENERGY-METABOLISM

KW - SUPPLEMENTATION

KW - ISOMERS

U2 - 10.1007/s11745-010-3480-6

DO - 10.1007/s11745-010-3480-6

M3 - Article

SN - 0024-4201

VL - 45

SP - 1047

EP - 1051

JO - Lipids

JF - Lipids

IS - 11

ER -