Comparison of Intraoperative gamma-Probe Imaging and Postoperative SPECT/CT in Detection of Sentinel Nodes Related to the Ovary

Stephanie C. J. M. Speth, Roy F. P. M. Kruitwagen*, Marjolein Kleppe, Ivo N. A. Pooters, Toon Van Gorp, Brigitte F. M. Slangen, Boudewijn Brans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Web of Science)
2 Downloads (Pure)


Tracer injection into ovarian ligaments has been shown to detect sentinel nodes (SNs) in patients with ovarian cancer. To determine the possibility that SNs are missed, this feasibility study compared their detection during surgery with their detection on postoperative SPECT/CT. Methods: In 8 patients (with either ovarian or endometrial cancer), after a staging lymphadenectomy including resection of SNs related to the ovary, SPECT/CT was performed within 24 h. Results: SPECT/CT identified hotspots in 4 patients at sites where SNs were resected. In 6 patients, additional sites were found, mainly in the pelvic region. Conclusion: Discrepancies between the gamma-probe and SPECT/CT may be due to missed SNs during surgery, but with respect to pelvic hotspots, in most cases they are more probably related to remnants of tracer at injection sites. With respect to sites where SNs were resected, remaining hotspots may have been caused by residual lymphatic flow after resection.
Original languageEnglish
Pages (from-to)243-245
Number of pages3
JournalJournal of Nuclear Medicine
Issue number2
Publication statusPublished - Feb 2017


  • sentinel node
  • ovarian cancer

Cite this