Comparison of Effects of Anti-thrombin Aptamers HD1 and HD22 on Aggregation of Human Platelets, Thrombin Generation, Fibrin Formation, and Thrombus Formation Under Flow Conditions

Katarzyna Derszniak, Kamil Przyborowski, Karolina Matyjaszczyk, Martijn Moorlag, Bas de Laat, Maria Nowakowska, Stefan Chlopicki*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number68
Number of pages13
JournalFrontiers in Pharmacology
Volume10
DOIs
Publication statusPublished - 20 Feb 2019

Keywords

  • aptamers
  • platelets
  • thrombin generation
  • fibrin generation
  • thrombus formation
  • VON-WILLEBRAND-FACTOR
  • BINDING DNA APTAMER
  • ALLOSTERIC LINKAGE
  • BLOOD-COAGULATION
  • INHIBITS THROMBIN
  • HIGH-AFFINITY
  • EXOSITE-I
  • ACTIVATION
  • COLLAGEN
  • PROTHROMBIN

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