Abstract
Background: In this study, we conducted an analytic hierarchy process (AHP) and a discrete choice experiment (DCE) to elicit the preferences of patients with age-related macular degeneration using identical attributes and levels. Objectives: To compare preference based weights for age-related macular degeneration treatment attributes and levels generated by two elicitation methods. The properties of both methods were assessed, including ease of instrument use. Methods: A DCE and an AHP experiment were designed on the basis of five attributes. Preference-based weights were generated using the matrix multiplication method for attributes and levels in AHP and a mixed multinomial logit model for levels in the DCE. Attribute importance was further compared using coefficient (DCE) and weight (AHP) level ranges. The questionnaire difficulty was rated on a qualitative scale. Patients were asked to think aloud while providing their judgments. Results: AHP and DCE generated similar results regarding levels, stressing a preference for visual improvement, frequent monitoring, on-demand and less frequent injection schemes, approved drugs, and mild side effects. Attribute weights derived on the basis of level ranges led to a ranking that was opposite to the AHP directly calculated attribute weights. For example, visual function ranked first in the AHP and last on the basis of level ranges. Conclusions: The results across the methods were similar, with one exception: the directly measured AHP attribute weights were different from the level-based interpretation of attribute importance in both DCE and AHP. The dependence/independence of attribute importance on level ranges in DCE and AHP, respectively, should be taken into account when choosing a method to support decision making.
Original language | English |
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Pages (from-to) | 1166-1173 |
Number of pages | 8 |
Journal | Value in Health |
Volume | 20 |
Issue number | 8 |
DOIs | |
Publication status | Published - Sept 2017 |
Keywords
- age-related macular degeneration
- analytic hierarchy process
- convergent validity
- discrete choice experiment
- patient preference(s)
- MULTICRITERIA DECISION-ANALYSIS
- ELDERLY OPHTHALMOLOGIC PATIENTS
- OF-THE-LITERATURE
- CONJOINT-ANALYSIS
- HEALTH-CARE
- TASK-FORCE
- TUTORIAL
- INSIGHTS