TY - JOUR
T1 - Comparative Electromechanical and Hemodynamic Effects of Left Ventricular and Biventricular Pacing in Dyssynchronous Heart Failure Electrical Resynchronization Versus Left-Right Ventricular Interaction
AU - Lumens, Joost
AU - Ploux, Sylvain
AU - Strik, Marc
AU - Gorcsan, John, III
AU - Cochet, Hubert
AU - Derval, Nicolas
AU - Strom, Maria
AU - Ramanathan, Charu
AU - Ritter, Philippe
AU - Haissaguerre, Michel
AU - Jais, Pierre
AU - Arts, Theo
AU - Delhaas, Tammo
AU - Prinzen, Frits W.
AU - Bordachar, Pierre
PY - 2013/12/24
Y1 - 2013/12/24
N2 - Objectives The purpose of this study was to enhance understanding of the working mechanism of cardiac resynchronization therapy by comparing animal experimental, clinical, and computational data on the hemodynamic and electromechanical consequences of left ventricular pacing (LVP) and biventricular pacing (BiVP). Background It is unclear why LVP and BiVP have comparative positive effects on hemodynamic function of patients with dyssynchronous heart failure. Methods Hemodynamic response to LVP and BiVP (% change in maximal rate of left ventricular pressure rise [LVdP/dt(max)]) was measured in 6 dogs and 24 patients with heart failure and left bundle branch block followed by computer simulations of local myofiber mechanics during LVP and BiVP in the failing heart with left bundle branch block. Pacing-induced changes of electrical activation were measured in dogs using contact mapping and in patients using a noninvasive multielectrode electrocardiographic mapping technique. Results LVP and BiVP similarly increased LVdP/dt(max) in dogs and in patients, but only BiVP significantly decreased electrical dyssynchrony. In the simulations, LVP and BiVP increased total ventricular myofiber work to the same extent. While the LVP-induced increase was entirely due to enhanced right ventricular (RV) myofiber work, the BiVP-induced increase was due to enhanced myofiber work of both the left ventricle (LV) and RV. Overall, LVdP/dt(max) correlated better with total ventricular myofiber work than with LV or RV myofiber work alone. Conclusions Animal experimental, clinical, and computational data support the similarity of hemodynamic response to LVP and BiVP, despite differences in electrical dyssynchrony. The simulations provide the novel insight that, through ventricular interaction, the RV myocardium importantly contributes to the improvement in LV pump function induced by cardiac resynchronization therapy.
AB - Objectives The purpose of this study was to enhance understanding of the working mechanism of cardiac resynchronization therapy by comparing animal experimental, clinical, and computational data on the hemodynamic and electromechanical consequences of left ventricular pacing (LVP) and biventricular pacing (BiVP). Background It is unclear why LVP and BiVP have comparative positive effects on hemodynamic function of patients with dyssynchronous heart failure. Methods Hemodynamic response to LVP and BiVP (% change in maximal rate of left ventricular pressure rise [LVdP/dt(max)]) was measured in 6 dogs and 24 patients with heart failure and left bundle branch block followed by computer simulations of local myofiber mechanics during LVP and BiVP in the failing heart with left bundle branch block. Pacing-induced changes of electrical activation were measured in dogs using contact mapping and in patients using a noninvasive multielectrode electrocardiographic mapping technique. Results LVP and BiVP similarly increased LVdP/dt(max) in dogs and in patients, but only BiVP significantly decreased electrical dyssynchrony. In the simulations, LVP and BiVP increased total ventricular myofiber work to the same extent. While the LVP-induced increase was entirely due to enhanced right ventricular (RV) myofiber work, the BiVP-induced increase was due to enhanced myofiber work of both the left ventricle (LV) and RV. Overall, LVdP/dt(max) correlated better with total ventricular myofiber work than with LV or RV myofiber work alone. Conclusions Animal experimental, clinical, and computational data support the similarity of hemodynamic response to LVP and BiVP, despite differences in electrical dyssynchrony. The simulations provide the novel insight that, through ventricular interaction, the RV myocardium importantly contributes to the improvement in LV pump function induced by cardiac resynchronization therapy.
KW - ventricular interaction
KW - myocardial work
KW - cardiac resynchronization therapy
KW - dyssynchrony
KW - electrophysiology mapping
U2 - 10.1016/j.jacc.2013.08.715
DO - 10.1016/j.jacc.2013.08.715
M3 - Article
C2 - 24013057
SN - 0735-1097
VL - 62
SP - 2395
EP - 2403
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 25
ER -