Common variants at VRK2 and TCF4 conferring risk of schizophrenia

Irish Schizophrenia Genomics ; GROUP ; Wellcome Trust Case Control, Jim van Os, Kari Stefansson*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

146 Citations (Web of Science)

Abstract

Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 x 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
Original languageEnglish
Pages (from-to)4076-4081
JournalHuman Molecular Genetics
Volume20
Issue number20
DOIs
Publication statusPublished - 15 Oct 2011

Cite this