TY - JOUR
T1 - Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction A Meta-analysis
AU - Den Ruijter, Hester M.
AU - Peters, Sanne A. E.
AU - Anderson, Todd J.
AU - Britton, Annie R.
AU - Dekker, Jacqueline M.
AU - Eijkemans, Marinus J.
AU - Engstrom, Gunnar
AU - Evans, Gregory W.
AU - de Graaf, Jacqueline
AU - Grobbee, Diederick E.
AU - Hedblad, Bo
AU - Hofman, Albert
AU - Holewijn, Suzanne
AU - Ikeda, Ai
AU - Kavousi, Maryam
AU - Kitagawa, Kazuo
AU - Kitamura, Akihiko
AU - Koffijberg, Hendrik
AU - Lonn, Eva M.
AU - Lorenz, Matthias W.
AU - Mathiesen, Ellisiv B.
AU - Nijpels, Giel
AU - Okazaki, Shuhei
AU - O'Leary, Daniel H.
AU - Polak, Joseph F.
AU - Price, Jackie F.
AU - Robertson, Christine
AU - Rembold, Christopher M.
AU - Rosvall, Maria
AU - Rundek, Tatjana
AU - Salonen, Jukka T.
AU - Sitzer, Matthias
AU - Stehouwer, Coen D. A.
AU - Witteman, Jacqueline C.
AU - Moons, Karel G.
AU - Bots, Michiel L.
PY - 2012/8/22
Y1 - 2012/8/22
N2 - Context The evidence that measurement of the common carotid intima-media thickness (CIMT) improves the risk scores in prediction of the absolute risk of cardiovascular events is inconsistent. Objective To determine whether common CIMT has added value in 10-year risk prediction of first-time myocardial infarctions or strokes, above that of the Framingham Risk Score. Data Sources Relevant studies were identified through literature searches of databases (PubMed from 1950 to June 2012 and EMBASE from 1980 to June 2012) and expert opinion. Study Selection Studies were included if participants were drawn from the general population, common CIMT was measured at baseline, and individuals were followed up for first-time myocardial infarction or stroke. Data Extraction Individual data were combined into 1 data set and an individual participant data meta-analysis was performed on individuals without existing cardiovascular disease. Results We included 14 population-based cohorts contributing data for 45 828 individuals. During a median follow-up of 11 years, 4007 first-time myocardial infarctions or strokes occurred. We first refitted the risk factors of the Framingham Risk Score and then extended the model with common CIMT measurements to estimate the absolute 10-year risks to develop a first-time myocardial infarction or stroke in both models. The C statistic of both models was similar (0.757; 95% CI, 0.749-0.764; and 0.759; 95% CI, 0.752-0.766). The net reclassification improvement with the addition of common CIMT was small (0.8%; 95% CI, 0.1%-1.6%). In those at intermediate risk, the net reclassification improvement was 3.6% in all individuals (95% CI, 2.7%-4.6%) and no differences between men and women. Conclusion The addition of common CIMT measurements to the Framingham Risk Score was associated with small improvement in 10-year risk prediction of first-time myocardial infarction or stroke, but this improvement is unlikely to be of clinical importance. JAMA. 2012;308(8):796-803 www.jama.com
AB - Context The evidence that measurement of the common carotid intima-media thickness (CIMT) improves the risk scores in prediction of the absolute risk of cardiovascular events is inconsistent. Objective To determine whether common CIMT has added value in 10-year risk prediction of first-time myocardial infarctions or strokes, above that of the Framingham Risk Score. Data Sources Relevant studies were identified through literature searches of databases (PubMed from 1950 to June 2012 and EMBASE from 1980 to June 2012) and expert opinion. Study Selection Studies were included if participants were drawn from the general population, common CIMT was measured at baseline, and individuals were followed up for first-time myocardial infarction or stroke. Data Extraction Individual data were combined into 1 data set and an individual participant data meta-analysis was performed on individuals without existing cardiovascular disease. Results We included 14 population-based cohorts contributing data for 45 828 individuals. During a median follow-up of 11 years, 4007 first-time myocardial infarctions or strokes occurred. We first refitted the risk factors of the Framingham Risk Score and then extended the model with common CIMT measurements to estimate the absolute 10-year risks to develop a first-time myocardial infarction or stroke in both models. The C statistic of both models was similar (0.757; 95% CI, 0.749-0.764; and 0.759; 95% CI, 0.752-0.766). The net reclassification improvement with the addition of common CIMT was small (0.8%; 95% CI, 0.1%-1.6%). In those at intermediate risk, the net reclassification improvement was 3.6% in all individuals (95% CI, 2.7%-4.6%) and no differences between men and women. Conclusion The addition of common CIMT measurements to the Framingham Risk Score was associated with small improvement in 10-year risk prediction of first-time myocardial infarction or stroke, but this improvement is unlikely to be of clinical importance. JAMA. 2012;308(8):796-803 www.jama.com
U2 - 10.1001/jama.2012.9630
DO - 10.1001/jama.2012.9630
M3 - Article
C2 - 22910757
SN - 0098-7484
VL - 308
SP - 796
EP - 803
JO - JAMA-Journal of the American Medical Association
JF - JAMA-Journal of the American Medical Association
IS - 8
ER -