Combining radiotherapy with immunotherapy: the past, the present and the future

Evert J. Van Limbergen*, Dirk K. De Ruysscher, Veronica Olivo Pimentel, Damienne Marcus, Maaike Berbee, Ann Hoeben, Nicolle Rekers, Jan Theys, Ala Yaromina, Ludwig J. Dubois, Philippe Lambin

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

66 Citations (Web of Science)

Abstract

The advent of immunotherapy is currently revolutionizing the field of oncology, where different drugs are used to stimulate different steps in a failing cancer immune response chain. This review gives a basic overview of the immune response against cancer, as well as the historical and current evidence on the interaction of radiotherapy with the immune system and the different forms of immunotherapy. Furthermore the review elaborates on the many open questions on how to exploit this interaction to the full extent in clinical practice.

Original languageEnglish
Article number20170157
Number of pages9
JournalBritish Journal of Radiology
Volume90
Issue number1076
DOIs
Publication statusPublished - 2017

Keywords

  • CELL LUNG-CANCER
  • REGULATORY T-CELLS
  • RESISTANT PROSTATE-CANCER
  • LOCAL RADIOTHERAPY
  • TUMOR-CELLS
  • PRECLINICAL RATIONALE
  • ANTITUMOR IMMUNITY
  • RADIATION-THERAPY
  • COMPLETE RESPONSE
  • MELANOMA

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