Combining radiotherapy with immunotherapy: the past, the present and the future

Evert J. Van Limbergen; Dirk K. De Ruysscher; Veronica Olivo Pimentel; Damienne Marcus; Maaike Berbee; Ann Hoeben; Nicolle Rekers; Jan Theys; Ala Yaromina; Ludwig J. Dubois; Philippe Lambin

doi:10.1259/bjr.20170157

Combining radiotherapy with immunotherapy: the past, the present and the future

Evert J. Van Limbergen^*, Dirk K. De Ruysscher, Veronica Olivo Pimentel, Damienne Marcus, Maaike Berbee, Ann Hoeben, Nicolle Rekers, Jan Theys, Ala Yaromina, Ludwig J. Dubois, Philippe Lambin

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The advent of immunotherapy is currently revolutionizing the field of oncology, where different drugs are used to stimulate different steps in a failing cancer immune response chain. This review gives a basic overview of the immune response against cancer, as well as the historical and current evidence on the interaction of radiotherapy with the immune system and the different forms of immunotherapy. Furthermore the review elaborates on the many open questions on how to exploit this interaction to the full extent in clinical practice.

Original language	English
Article number	20170157
Number of pages	9
Journal	British Journal of Radiology
Volume	90
Issue number	1076
DOIs	https://doi.org/10.1259/bjr.20170157
Publication status	Published - 2017

Keywords

CELL LUNG-CANCER
REGULATORY T-CELLS
RESISTANT PROSTATE-CANCER
LOCAL RADIOTHERAPY
TUMOR-CELLS
PRECLINICAL RATIONALE
ANTITUMOR IMMUNITY
RADIATION-THERAPY
COMPLETE RESPONSE
MELANOMA

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10.1259/bjr.20170157Licence: CC BY-NC

Cite this

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title = "Combining radiotherapy with immunotherapy: the past, the present and the future",

abstract = "The advent of immunotherapy is currently revolutionizing the field of oncology, where different drugs are used to stimulate different steps in a failing cancer immune response chain. This review gives a basic overview of the immune response against cancer, as well as the historical and current evidence on the interaction of radiotherapy with the immune system and the different forms of immunotherapy. Furthermore the review elaborates on the many open questions on how to exploit this interaction to the full extent in clinical practice.",

keywords = "CELL LUNG-CANCER, REGULATORY T-CELLS, RESISTANT PROSTATE-CANCER, LOCAL RADIOTHERAPY, TUMOR-CELLS, PRECLINICAL RATIONALE, ANTITUMOR IMMUNITY, RADIATION-THERAPY, COMPLETE RESPONSE, MELANOMA",

author = "{Van Limbergen}, {Evert J.} and {De Ruysscher}, {Dirk K.} and Pimentel, {Veronica Olivo} and Damienne Marcus and Maaike Berbee and Ann Hoeben and Nicolle Rekers and Jan Theys and Ala Yaromina and Dubois, {Ludwig J.} and Philippe Lambin",

year = "2017",

doi = "10.1259/bjr.20170157",

language = "English",

volume = "90",

journal = "British Journal of Radiology",

issn = "0007-1285",

publisher = "British Institute of Radiology",

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AU - Van Limbergen, Evert J.

AU - De Ruysscher, Dirk K.

AU - Pimentel, Veronica Olivo

AU - Marcus, Damienne

AU - Berbee, Maaike

AU - Hoeben, Ann

AU - Rekers, Nicolle

AU - Theys, Jan

AU - Yaromina, Ala

AU - Dubois, Ludwig J.

AU - Lambin, Philippe

PY - 2017

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AB - The advent of immunotherapy is currently revolutionizing the field of oncology, where different drugs are used to stimulate different steps in a failing cancer immune response chain. This review gives a basic overview of the immune response against cancer, as well as the historical and current evidence on the interaction of radiotherapy with the immune system and the different forms of immunotherapy. Furthermore the review elaborates on the many open questions on how to exploit this interaction to the full extent in clinical practice.

KW - CELL LUNG-CANCER

KW - REGULATORY T-CELLS

KW - RESISTANT PROSTATE-CANCER

KW - LOCAL RADIOTHERAPY

KW - TUMOR-CELLS

KW - PRECLINICAL RATIONALE

KW - ANTITUMOR IMMUNITY

KW - RADIATION-THERAPY

KW - COMPLETE RESPONSE

KW - MELANOMA

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DO - 10.1259/bjr.20170157

M3 - (Systematic) Review article

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VL - 90

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