Combining Catalyst-Free Click Chemistry with Coaxial Electrospinning to Obtain Long-Term, Water-Stable, Bioactive Elastin-Like Fibers for Tissue Engineering Applications

Alicia Fernandez-Colino*, Frederic Wolf, Stephan Rutten, Jose Carlos Rodriguez-Cabello, Stefan Jockenhoevel, Petra Mela*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)

Abstract

Elastic fibers are a fundamental requirement for tissue-engineered equivalents of physiologically elastic native tissues. Here, a simple one-step electrospinning approach is developed, combining i) catalyst-free click chemistry, ii) coaxial electrospinning, and iii) recombinant elastin-like polymers as a relevant class of biomaterials. Water-stable elastin-like fibers are obtained without the use of cross-linking agents, catalysts, or harmful organic solvents. The fibers can be directly exposed to an aqueous environment at physiological temperature and their morphology maintained for at least 3 months. The bioactivity of the fibers is demonstrated with human vascular cells and the potential of the process for vascular tissue engineering is shown by fabricating small-diameter tubular fibrous scaffolds. Moreover, highly porous fluffy 3D constructs are obtained without the use of specially designed collectors or sacrificial materials, further supporting their applicability in the biomedical field. Ultimately, the strategy that is developed here may be applied to other click systems, contributing to expanding their potential in medical technology.
Original languageEnglish
Article number1800147
Number of pages7
JournalMacromolecular Bioscience
Volume18
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • cardiovascular
  • click chemistry
  • coaxial electrospinning
  • elastin-like fibers
  • one-step processes
  • NANOFIBROUS SCAFFOLDS
  • FABRICATION
  • BIOCONJUGATION
  • PROLIFERATION
  • RECOMBINAMERS
  • STRATEGIES
  • DIAMETER
  • ADHESION
  • MATRICES
  • DESIGN

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