Combination of noninvasive brain stimulation and constraint-induced movement therapy in patients with stroke: a systematic review and meta-analysis

Auwal Abdullahi; Thomson Wl Wong; Tamaya Van Criekinge; Shamay Sm Ng

doi:10.1080/14737175.2023.2177154

Combination of noninvasive brain stimulation and constraint-induced movement therapy in patients with stroke: a systematic review and meta-analysis

Auwal Abdullahi, Thomson Wl Wong, Tamaya Van Criekinge, Shamay Sm Ng

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

INTRODUCTION: Constraint-induced movement therapy (CIMT) and noninvasive brain stimulation (NIBS) are used to counteract learned nonuse phenomenon and imbalance in interhemispheric inhibition following stroke. The aim of this study is to summarize the available evidence on the effects of combining NIBS with CIMT in patients with stroke.

METHOD: PubMed, Embase, Web of Science (WoS), PEDro, OTSeeker, and CENTRAL were searched for randomized controlled trials comparing the use of NIBS+CIMT with sham NIBS+CIMT. Data on variables such as time since stroke and mean scores and standard deviations on outcomes assessed such as motor function were extracted. Cochrane risks of bias assessment tool and PEDro scale were used to assess the risk of bias and methodological quality of the included studies.

RESULTS: The results showed that both NIBS+CIMT and sham NIBS+CIMT improved all outcomes post-intervention and at follow-up. However, NIBS+CIMT is superior to sham NIBS+CIMT at improving level of motor impairment (SMD = 1.75, 95% CI = 0.49 to 3.01, P = 0.007) post-intervention and hand function (SMD = 1.21, 95% CI = 0.07 to 2.35, P = 0.04) at follow-up.

CONCLUSIONS: The addition of NIBS to CIMT seems to provide additional benefits to the recovery of function following stroke.

Original language	English
Pages (from-to)	187-203
Number of pages	17
Journal	Expert Review of Neurotherapeutics
Volume	23
Issue number	2
DOIs	https://doi.org/10.1080/14737175.2023.2177154
Publication status	Published - Feb 2023
Externally published	Yes

Keywords

Humans
Stroke Rehabilitation/methods
Stroke/therapy
Movement
Brain

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10.1080/14737175.2023.2177154

Cite this

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title = "Combination of noninvasive brain stimulation and constraint-induced movement therapy in patients with stroke: a systematic review and meta-analysis",

abstract = "INTRODUCTION: Constraint-induced movement therapy (CIMT) and noninvasive brain stimulation (NIBS) are used to counteract learned nonuse phenomenon and imbalance in interhemispheric inhibition following stroke. The aim of this study is to summarize the available evidence on the effects of combining NIBS with CIMT in patients with stroke.METHOD: PubMed, Embase, Web of Science (WoS), PEDro, OTSeeker, and CENTRAL were searched for randomized controlled trials comparing the use of NIBS+CIMT with sham NIBS+CIMT. Data on variables such as time since stroke and mean scores and standard deviations on outcomes assessed such as motor function were extracted. Cochrane risks of bias assessment tool and PEDro scale were used to assess the risk of bias and methodological quality of the included studies.RESULTS: The results showed that both NIBS+CIMT and sham NIBS+CIMT improved all outcomes post-intervention and at follow-up. However, NIBS+CIMT is superior to sham NIBS+CIMT at improving level of motor impairment (SMD = 1.75, 95% CI = 0.49 to 3.01, P = 0.007) post-intervention and hand function (SMD = 1.21, 95% CI = 0.07 to 2.35, P = 0.04) at follow-up.CONCLUSIONS: The addition of NIBS to CIMT seems to provide additional benefits to the recovery of function following stroke.",

keywords = "Humans, Stroke Rehabilitation/methods, Stroke/therapy, Movement, Brain",

author = "Auwal Abdullahi and Wong, {Thomson Wl} and {Van Criekinge}, Tamaya and Ng, {Shamay Sm}",

year = "2023",

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doi = "10.1080/14737175.2023.2177154",

language = "English",

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Combination of noninvasive brain stimulation and constraint-induced movement therapy in patients with stroke: a systematic review and meta-analysis. / Abdullahi, Auwal; Wong, Thomson Wl; Van Criekinge, Tamaya et al.
In: Expert Review of Neurotherapeutics, Vol. 23, No. 2, 02.2023, p. 187-203.

Research output: Contribution to journal › (Systematic) Review article › peer-review

TY - JOUR

T1 - Combination of noninvasive brain stimulation and constraint-induced movement therapy in patients with stroke

T2 - a systematic review and meta-analysis

AU - Abdullahi, Auwal

AU - Wong, Thomson Wl

AU - Van Criekinge, Tamaya

AU - Ng, Shamay Sm

PY - 2023/2

Y1 - 2023/2

N2 - INTRODUCTION: Constraint-induced movement therapy (CIMT) and noninvasive brain stimulation (NIBS) are used to counteract learned nonuse phenomenon and imbalance in interhemispheric inhibition following stroke. The aim of this study is to summarize the available evidence on the effects of combining NIBS with CIMT in patients with stroke.METHOD: PubMed, Embase, Web of Science (WoS), PEDro, OTSeeker, and CENTRAL were searched for randomized controlled trials comparing the use of NIBS+CIMT with sham NIBS+CIMT. Data on variables such as time since stroke and mean scores and standard deviations on outcomes assessed such as motor function were extracted. Cochrane risks of bias assessment tool and PEDro scale were used to assess the risk of bias and methodological quality of the included studies.RESULTS: The results showed that both NIBS+CIMT and sham NIBS+CIMT improved all outcomes post-intervention and at follow-up. However, NIBS+CIMT is superior to sham NIBS+CIMT at improving level of motor impairment (SMD = 1.75, 95% CI = 0.49 to 3.01, P = 0.007) post-intervention and hand function (SMD = 1.21, 95% CI = 0.07 to 2.35, P = 0.04) at follow-up.CONCLUSIONS: The addition of NIBS to CIMT seems to provide additional benefits to the recovery of function following stroke.

AB - INTRODUCTION: Constraint-induced movement therapy (CIMT) and noninvasive brain stimulation (NIBS) are used to counteract learned nonuse phenomenon and imbalance in interhemispheric inhibition following stroke. The aim of this study is to summarize the available evidence on the effects of combining NIBS with CIMT in patients with stroke.METHOD: PubMed, Embase, Web of Science (WoS), PEDro, OTSeeker, and CENTRAL were searched for randomized controlled trials comparing the use of NIBS+CIMT with sham NIBS+CIMT. Data on variables such as time since stroke and mean scores and standard deviations on outcomes assessed such as motor function were extracted. Cochrane risks of bias assessment tool and PEDro scale were used to assess the risk of bias and methodological quality of the included studies.RESULTS: The results showed that both NIBS+CIMT and sham NIBS+CIMT improved all outcomes post-intervention and at follow-up. However, NIBS+CIMT is superior to sham NIBS+CIMT at improving level of motor impairment (SMD = 1.75, 95% CI = 0.49 to 3.01, P = 0.007) post-intervention and hand function (SMD = 1.21, 95% CI = 0.07 to 2.35, P = 0.04) at follow-up.CONCLUSIONS: The addition of NIBS to CIMT seems to provide additional benefits to the recovery of function following stroke.

KW - Humans

KW - Stroke Rehabilitation/methods

KW - Stroke/therapy

KW - Movement

KW - Brain

U2 - 10.1080/14737175.2023.2177154

DO - 10.1080/14737175.2023.2177154

M3 - (Systematic) Review article

C2 - 36745928

SN - 1473-7175

VL - 23

SP - 187

EP - 203

JO - Expert Review of Neurotherapeutics

JF - Expert Review of Neurotherapeutics

IS - 2

ER -

Combination of noninvasive brain stimulation and constraint-induced movement therapy in patients with stroke: a systematic review and meta-analysis

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Keywords

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