Combination drug delivery approaches in ophthalmology

Christian Bertens, Marlies Gijs, Jarno Wolters, Helena Beckers, Rudy Nuijts

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic


For the treatment and prevention of ocular diseases, eye drops or ointments are generally prescribed to patients. However, these conventional drug formulations suffer from low patient compliance and deliver a suboptimal low drug concentration at the target site. Therefore, new drug–device combinations are being explored to improve drug delivery to the eye.

Various drug–device combinations have been developed in the last few decades, while only a few have made it to the market. In this chapter, we provide a comprehensive overview of drug–device combinations that have reached the final preclinical and clinical stages. We focus on devices that are marketed for ocular diseases such as glaucoma, dry eye disease, infections, and inflammations. Furthermore, drug delivery devices for ocular surgeries are discussed.
Original languageEnglish
Title of host publicationCombination Drug Delivery Approach as an Effective Therapy for Various Diseases
EditorsPrashant Kesharwani
Number of pages17
ISBN (Print)9780323858731
Publication statusPublished - 2022


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