Collagen Biomineralization In Vivo by Sustained Release of Inorganic Phosphate Ions

Pamela Habibovic; David C. Bassett; Charles J. Doillon; Catherine Gerard; Marc D. McKee; Jake E. Barralet

doi:10.1002/adma.200902778

Collagen Biomineralization In Vivo by Sustained Release of Inorganic Phosphate Ions

Pamela Habibovic, David C. Bassett, Charles J. Doillon, Catherine Gerard, Marc D. McKee, Jake E. Barralet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

Original language	English
Pages (from-to)	1858-1862
Number of pages	6
Journal	Advanced Materials
Volume	22
Issue number	16
DOIs	https://doi.org/10.1002/adma.200902778
Publication status	Published - 22 Apr 2010
Externally published	Yes

Keywords

ALKALINE-PHOSPHATASE
ACRYLIC HYDROGELS
MINERALIZATION
PYROPHOSPHATE
HYDROXYAPATITE
CALCIFICATION
SCAFFOLDS
SOLUTE
SERUM
RAT

Access to Document

10.1002/adma.200902778

Cite this

@article{aa0c439c0db04a3bbeb17a3c34e83b7e,

title = "Collagen Biomineralization In Vivo by Sustained Release of Inorganic Phosphate Ions",

abstract = "A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.",

keywords = "ALKALINE-PHOSPHATASE, ACRYLIC HYDROGELS, MINERALIZATION, PYROPHOSPHATE, HYDROXYAPATITE, CALCIFICATION, SCAFFOLDS, SOLUTE, SERUM, RAT",

author = "Pamela Habibovic and Bassett, {David C.} and Doillon, {Charles J.} and Catherine Gerard and McKee, {Marc D.} and Barralet, {Jake E.}",

year = "2010",

month = apr,

day = "22",

doi = "10.1002/adma.200902778",

language = "English",

volume = "22",

pages = "1858--1862",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "16",

}

TY - JOUR

T1 - Collagen Biomineralization In Vivo by Sustained Release of Inorganic Phosphate Ions

AU - Habibovic, Pamela

AU - Bassett, David C.

AU - Doillon, Charles J.

AU - Gerard, Catherine

AU - McKee, Marc D.

AU - Barralet, Jake E.

PY - 2010/4/22

Y1 - 2010/4/22

N2 - A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

AB - A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

KW - ALKALINE-PHOSPHATASE

KW - ACRYLIC HYDROGELS

KW - MINERALIZATION

KW - PYROPHOSPHATE

KW - HYDROXYAPATITE

KW - CALCIFICATION

KW - SCAFFOLDS

KW - SOLUTE

KW - SERUM

KW - RAT

U2 - 10.1002/adma.200902778

DO - 10.1002/adma.200902778

M3 - Article

SN - 0935-9648

VL - 22

SP - 1858

EP - 1862

JO - Advanced Materials

JF - Advanced Materials

IS - 16

ER -