Collagen Biomineralization In Vivo by Sustained Release of Inorganic Phosphate Ions

Pamela Habibovic, David C. Bassett, Charles J. Doillon, Catherine Gerard, Marc D. McKee, Jake E. Barralet*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

Original languageEnglish
Pages (from-to)1858-1862
Number of pages6
JournalAdvanced Materials
Volume22
Issue number16
DOIs
Publication statusPublished - 22 Apr 2010
Externally publishedYes

Keywords

  • ALKALINE-PHOSPHATASE
  • ACRYLIC HYDROGELS
  • MINERALIZATION
  • PYROPHOSPHATE
  • HYDROXYAPATITE
  • CALCIFICATION
  • SCAFFOLDS
  • SOLUTE
  • SERUM
  • RAT

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