Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach

Philippos Koulousakis; Daniel van den Hove; Veerle Visser-Vandewalle; Thibaut Sesia

doi:10.3233/JAD-190919

Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach

Philippos Koulousakis^*
, Daniel van den Hove
, Veerle Visser-Vandewalle
, Thibaut Sesia

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been shown to exert promising therapeutical effects in a pilot study with patients suffering from Alzheimer's disease (AD). We aimed at comparing the cognitive effects of intermittent and continuous NBM stimulation paradigms in an animal model for AD. In this exploratory study, aged Tgf344-AD rats were behaviorally tested pre-, and post implantation, while being stimulated with unilateral- or bilateral-intermittent and bilateral-continuous patterns. Bilateral-intermittent NBM DBS lead to supernormal performance in a spatial memory task. These findings suggest that NBM DBS could be further refined, thereby improving patient care.

Original language	English
Pages (from-to)	461-466
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	73
Issue number	2
DOIs	https://doi.org/10.3233/JAD-190919
Publication status	Published - 2020

Keywords

Alzheimer's disease
deep brain stimulation
intermittent stimulation
nucleus basalis of Meynert
NEURONS
BETA

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@article{36a2ead7f63e49c8931e95168263ab9a,

title = "Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach",

abstract = "Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been shown to exert promising therapeutical effects in a pilot study with patients suffering from Alzheimer's disease (AD). We aimed at comparing the cognitive effects of intermittent and continuous NBM stimulation paradigms in an animal model for AD. In this exploratory study, aged Tgf344-AD rats were behaviorally tested pre-, and post implantation, while being stimulated with unilateral- or bilateral-intermittent and bilateral-continuous patterns. Bilateral-intermittent NBM DBS lead to supernormal performance in a spatial memory task. These findings suggest that NBM DBS could be further refined, thereby improving patient care.",

keywords = "Alzheimer's disease, deep brain stimulation, intermittent stimulation, nucleus basalis of Meynert, NEURONS, BETA",

author = "Philippos Koulousakis and \{van den Hove\}, Daniel and Veerle Visser-Vandewalle and Thibaut Sesia",

note = "Funding Information: This work was supported by the Department of Stereotactic and Functional Neurosurgery of the University Hospital of Cologne. Publisher Copyright: {\textcopyright} 2020 - IOS Press and the authors. All rights reserved.",

year = "2020",

doi = "10.3233/JAD-190919",

language = "English",

volume = "73",

pages = "461--466",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "SAGE Publications Ltd",

number = "2",

}

Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach. / Koulousakis, Philippos; van den Hove, Daniel; Visser-Vandewalle, Veerle et al.
In: Journal of Alzheimer's Disease, Vol. 73, No. 2, 2020, p. 461-466.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease

T2 - A Preliminary Approach

AU - Koulousakis, Philippos

AU - van den Hove, Daniel

AU - Visser-Vandewalle, Veerle

AU - Sesia, Thibaut

N1 - Funding Information: This work was supported by the Department of Stereotactic and Functional Neurosurgery of the University Hospital of Cologne. Publisher Copyright: © 2020 - IOS Press and the authors. All rights reserved.

PY - 2020

Y1 - 2020

N2 - Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been shown to exert promising therapeutical effects in a pilot study with patients suffering from Alzheimer's disease (AD). We aimed at comparing the cognitive effects of intermittent and continuous NBM stimulation paradigms in an animal model for AD. In this exploratory study, aged Tgf344-AD rats were behaviorally tested pre-, and post implantation, while being stimulated with unilateral- or bilateral-intermittent and bilateral-continuous patterns. Bilateral-intermittent NBM DBS lead to supernormal performance in a spatial memory task. These findings suggest that NBM DBS could be further refined, thereby improving patient care.

AB - Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been shown to exert promising therapeutical effects in a pilot study with patients suffering from Alzheimer's disease (AD). We aimed at comparing the cognitive effects of intermittent and continuous NBM stimulation paradigms in an animal model for AD. In this exploratory study, aged Tgf344-AD rats were behaviorally tested pre-, and post implantation, while being stimulated with unilateral- or bilateral-intermittent and bilateral-continuous patterns. Bilateral-intermittent NBM DBS lead to supernormal performance in a spatial memory task. These findings suggest that NBM DBS could be further refined, thereby improving patient care.

KW - Alzheimer's disease

KW - deep brain stimulation

KW - intermittent stimulation

KW - nucleus basalis of Meynert

KW - NEURONS

KW - BETA

U2 - 10.3233/JAD-190919

DO - 10.3233/JAD-190919

M3 - Article

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SN - 1387-2877

VL - 73

SP - 461

EP - 466

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 2

ER -

Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach

Abstract

Keywords

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