TY - JOUR
T1 - Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease
AU - Cleutjens, Fiona A. H. M.
AU - Spruit, Martijn A.
AU - Ponds, Rudolf W. H. M.
AU - Vanfleteren, Lowie E. G. W.
AU - Franssen, Frits M. E.
AU - Gijsen, Candy
AU - Dijkstra, Jeanette B.
AU - Wouters, Emiel F. M.
AU - Janssen, Daisy J. A.
PY - 2018/5
Y1 - 2018/5
N2 - We aimed to investigate (1) the relationship between cognitive impairment (CI) and disease severity and (2) the potential differences in exercise performance, daily activities, health status, and psychological well-being between patients with and without CI. Clinically stable chronic obstructive pulmonary disease (COPD) patients, referred for pulmonary rehabilitation, underwent a neuropsychological examination. Functional exercise capacity (6-minute walk test [6MWT]), daily activities (Canadian Occupational Performance Measure [COPM]), health status (COPD Assessment Test [CAT]) and St George's Respiratory Questionnaire-COPD specific [SGRQ-C]), and psychological well-being (Hospital Anxiety and Depression Scale [HADS], Beck Depression Inventory [BDI], and Symptom Checklist 90 [SCL-90]) were compared between patients with and without CI. Of 183 COPD patients (mean age 63.6 (9.4) years, FEV
1 54.8 (23.0%) predicted), 76 (41.5%) patients had CI. The prevalence was comparable across Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1-4 (44.8%, 40.0%, 41.0%, 43.5%, respectively, p = 0.97) and GOLD groups A-D (50.0%, 44.7%, 33.3%, 40.2%, respectively, p = 0.91). Patients with and without CI were comparable for demographics, smoking status, FEV
1% predicted, mMRC, 6MWT, COPM, CAT, HADS, BDI, and SCL-90 scores. Clinical characteristics of COPD patients with and without CI are comparable. Assessment of CI in COPD, thus, requires an active case-finding approach.
AB - We aimed to investigate (1) the relationship between cognitive impairment (CI) and disease severity and (2) the potential differences in exercise performance, daily activities, health status, and psychological well-being between patients with and without CI. Clinically stable chronic obstructive pulmonary disease (COPD) patients, referred for pulmonary rehabilitation, underwent a neuropsychological examination. Functional exercise capacity (6-minute walk test [6MWT]), daily activities (Canadian Occupational Performance Measure [COPM]), health status (COPD Assessment Test [CAT]) and St George's Respiratory Questionnaire-COPD specific [SGRQ-C]), and psychological well-being (Hospital Anxiety and Depression Scale [HADS], Beck Depression Inventory [BDI], and Symptom Checklist 90 [SCL-90]) were compared between patients with and without CI. Of 183 COPD patients (mean age 63.6 (9.4) years, FEV
1 54.8 (23.0%) predicted), 76 (41.5%) patients had CI. The prevalence was comparable across Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1-4 (44.8%, 40.0%, 41.0%, 43.5%, respectively, p = 0.97) and GOLD groups A-D (50.0%, 44.7%, 33.3%, 40.2%, respectively, p = 0.91). Patients with and without CI were comparable for demographics, smoking status, FEV
1% predicted, mMRC, 6MWT, COPM, CAT, HADS, BDI, and SCL-90 scores. Clinical characteristics of COPD patients with and without CI are comparable. Assessment of CI in COPD, thus, requires an active case-finding approach.
KW - COPD
KW - cognitive impairment
KW - functional status
KW - health status
KW - psychological well-being
KW - pulmonary rehabilitation
KW - QUALITY-OF-LIFE
KW - MEDICATION ADHERENCE
KW - COPD PATIENTS
KW - REHABILITATION
KW - DEPRESSION
KW - HEALTH
KW - VALIDATION
KW - DEMENTIA
KW - ADULTS
KW - METAANALYSIS
U2 - 10.1177/1479972317709651
DO - 10.1177/1479972317709651
M3 - Article
C2 - 28553720
SN - 1479-9723
VL - 15
SP - 91
EP - 102
JO - Chronic respiratory disease
JF - Chronic respiratory disease
IS - 2
ER -