Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease

Fiona A. H. M. Cleutjens*, Martijn A. Spruit, Rudolf W. H. M. Ponds, Lowie E. G. W. Vanfleteren, Frits M. E. Franssen, Candy Gijsen, Jeanette B. Dijkstra, Emiel F. M. Wouters, Daisy J. A. Janssen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We aimed to investigate (1) the relationship between cognitive impairment (CI) and disease severity and (2) the potential differences in exercise performance, daily activities, health status, and psychological well-being between patients with and without CI. Clinically stable chronic obstructive pulmonary disease (COPD) patients, referred for pulmonary rehabilitation, underwent a neuropsychological examination. Functional exercise capacity (6-minute walk test [6MWT]), daily activities (Canadian Occupational Performance Measure [COPM]), health status (COPD Assessment Test [CAT]) and St George's Respiratory Questionnaire-COPD specific [SGRQ-C]), and psychological well-being (Hospital Anxiety and Depression Scale [HADS], Beck Depression Inventory [BDI], and Symptom Checklist 90 [SCL-90]) were compared between patients with and without CI. Of 183 COPD patients (mean age 63.6 (9.4) years, FEV 1 54.8 (23.0%) predicted), 76 (41.5%) patients had CI. The prevalence was comparable across Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1-4 (44.8%, 40.0%, 41.0%, 43.5%, respectively, p = 0.97) and GOLD groups A-D (50.0%, 44.7%, 33.3%, 40.2%, respectively, p = 0.91). Patients with and without CI were comparable for demographics, smoking status, FEV 1% predicted, mMRC, 6MWT, COPM, CAT, HADS, BDI, and SCL-90 scores. Clinical characteristics of COPD patients with and without CI are comparable. Assessment of CI in COPD, thus, requires an active case-finding approach.

Original languageEnglish
Pages (from-to)91-102
Number of pages12
JournalChronic respiratory disease
Volume15
Issue number2
DOIs
Publication statusPublished - May 2018

Keywords

  • COPD
  • cognitive impairment
  • functional status
  • health status
  • psychological well-being
  • pulmonary rehabilitation
  • QUALITY-OF-LIFE
  • MEDICATION ADHERENCE
  • COPD PATIENTS
  • REHABILITATION
  • DEPRESSION
  • HEALTH
  • VALIDATION
  • DEMENTIA
  • ADULTS
  • METAANALYSIS

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