TY - JOUR
T1 - Cognitive Function in Acquired Bilateral Vestibulopathy
T2 - A Cross-Sectional Study on Cognition, Hearing, and Vestibular Loss
AU - Dobbels, Bieke
AU - Mertens, Grief
AU - Gilles, Annick
AU - Claes, Annes
AU - Moyaert, Julie
AU - van de Berg, Raymond
AU - Van de Heyning, Paul
AU - Vanderveken, Olivier
AU - Van Rompaey, Vincent
N1 - Funding Information:
This work was funded by the Federal State of Lower Saxony, Niedersächsisches Vorab CDiff and CDInfect projects (VWZN2889/3215/3266) as well as by the German Research Foundation and the Open Access Publication Funds of the Technische Universität Braunschweig.
Publisher Copyright:
© 2019 Dobbels, Mertens, Gilles, Moyaert, van de Berg, Van de Heyning, Vanderveken and Van Rompaey.
PY - 2019/4/24
Y1 - 2019/4/24
N2 - Background: Several studies have demonstrated cognitive deficits in patients with bilateral vestibulopathy (BVP). So far, little attention has been paid to the hearing status of vestibular patients when evaluating their cognition. Given the well-established link between sensorineural hearing loss (SNHL) and cognitive decline and the high prevalence of SNHL in BVP patients, it is therefore uncertain if the cognitive deficits in BVP patients are solely due to their vestibular loss or might be, partially, explained by a concomitant SNHL.Objective: To evaluate the link between cognition, hearing, and vestibular loss in BVP patients.Design: Prospective cross-sectional analysis of cognitive performance in patients with BVP and control participants without vestibular loss. Both groups included subjects with a variety of hearing (dys) function. Cognition was assessed by means of the Repeatable Battery for the Assessment of Neuropsychological Status for Hearing Impaired Individuals (RBANS-H).Results: Sixty-four BVP patients were evaluated and compared with 83 control participants. For each subscale and the totale RBANS-H scale a multiple linear regression model was fitted with the following variables: vestibular loss, hearing loss, age, gender, and education. Hearing loss seemed to be associated with worse outcome on the total RBANS-H scale and subscales immediate memory and language. Vestibular loss, on the other hand, was linked to worse performance on the attention subscale of the RBANS-H. Furthermore, we did not observe a correlation between saccular function and cognition.Conclusion: This study has found general cognitive deficits in a large sample size of BVP patients. Multiple linear regression models revealed that both vestibular and hearing dysfunction were associated with different subscales of the cognitive test battery, the RBANS-H. Whereas hearing loss was associated with worse performance on total RBANS-H score, immediate memory and language, vestibular loss was observed to negatively affect attention performance.
AB - Background: Several studies have demonstrated cognitive deficits in patients with bilateral vestibulopathy (BVP). So far, little attention has been paid to the hearing status of vestibular patients when evaluating their cognition. Given the well-established link between sensorineural hearing loss (SNHL) and cognitive decline and the high prevalence of SNHL in BVP patients, it is therefore uncertain if the cognitive deficits in BVP patients are solely due to their vestibular loss or might be, partially, explained by a concomitant SNHL.Objective: To evaluate the link between cognition, hearing, and vestibular loss in BVP patients.Design: Prospective cross-sectional analysis of cognitive performance in patients with BVP and control participants without vestibular loss. Both groups included subjects with a variety of hearing (dys) function. Cognition was assessed by means of the Repeatable Battery for the Assessment of Neuropsychological Status for Hearing Impaired Individuals (RBANS-H).Results: Sixty-four BVP patients were evaluated and compared with 83 control participants. For each subscale and the totale RBANS-H scale a multiple linear regression model was fitted with the following variables: vestibular loss, hearing loss, age, gender, and education. Hearing loss seemed to be associated with worse outcome on the total RBANS-H scale and subscales immediate memory and language. Vestibular loss, on the other hand, was linked to worse performance on the attention subscale of the RBANS-H. Furthermore, we did not observe a correlation between saccular function and cognition.Conclusion: This study has found general cognitive deficits in a large sample size of BVP patients. Multiple linear regression models revealed that both vestibular and hearing dysfunction were associated with different subscales of the cognitive test battery, the RBANS-H. Whereas hearing loss was associated with worse performance on total RBANS-H score, immediate memory and language, vestibular loss was observed to negatively affect attention performance.
KW - bilateral vestibulopathy
KW - hearing loss
KW - sensorineural
KW - COCH protein
KW - human
KW - causality
KW - cognition
KW - VISUOSPATIAL ABILITY
KW - SPATIAL NAVIGATION
KW - OLDER-ADULTS
KW - MEMORY
KW - TASK
KW - DEAFFERENTATION
KW - ASSOCIATION
KW - PERFORMANCE
KW - IMPAIRMENT
KW - DEMENTIA
U2 - 10.3389/fnins.2019.00340
DO - 10.3389/fnins.2019.00340
M3 - Article
C2 - 31105513
SN - 1662-453X
VL - 13
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 340
ER -