Coffee, tea, and caffeine intake and amyotrophic lateral sclerosis mortality in a pooled analysis of eight prospective cohort studies

J. Petimar*, E. O'Reilly, H. -O. Adami, P. A. van den Brandt, J. Buring, D. R. English, D. M. Freedman, G. G. Giles, N. Hakansson, T. Kurth, S. C. Larsson, K. Robien, L. J. Schouten, E. Weiderpass, A. Wolk, S. A. Smith-Warner

*Corresponding author for this work

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Abstract

Background and purposeCaffeine is associated with a lower risk of some neurological diseases, but few prospective studies have investigated caffeine intake and risk of amyotrophic lateral sclerosis (ALS) mortality. We therefore determined associations between coffee, tea and caffeine intake, and risk of ALS mortality.

MethodsWe conducted pooled analyses of eight international, prospective cohort studies, including 351565 individuals (120688 men and 230877 women). We assessed coffee, tea and caffeine intake using validated food-frequency questionnaires administered at baseline. We used Cox regression to estimate study- and sex-specific risk ratios and 95% confidence intervals (CI) for ALS mortality, which were then pooled using a random-effects model. We conducted analyses using cohort-specific tertiles, absolute common cut-points and continuous measures of all exposures.

ResultsDuring follow-up, 545 ALS deaths were documented. We did not observe statistically significant associations between coffee, tea or caffeine intake and risk of ALS mortality. The pooled multivariable risk ratio (MVRR) for 3 cups per day vs. >0 to

ConclusionsOur results do not support associations between coffee, tea or total caffeine intake and risk of ALS mortality.

Original languageEnglish
Pages (from-to)468-475
Number of pages8
JournalEuropean Journal of Neurology
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • amyotrophic lateral sclerosis
  • caffeine
  • coffee
  • pooled analyses
  • prospective cohort studies
  • tea
  • FOOD FREQUENCY QUESTIONNAIRE
  • SCALE PROSPECTIVE COHORT
  • COLORECTAL-CANCER RISK
  • DIETARY QUESTIONNAIRE
  • NUTRIENT INTAKE
  • REPRODUCIBILITY
  • VALIDITY
  • CONSUMPTION
  • VALIDATION
  • ACCURACY

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