Abstract
Aim: A dose-response meta-analysis was conducted in order to summarize the evidence from prospective cohort studies regarding the association between coffee intake and breast cancer risk. Methods: A systematic search was performed in electronic databases up to March 2017 to identify relevant studies; risk estimates were retrieved from the studies and linear and non-linear dose-response analysis modelled by restricted cubic splines was conducted. A stratified and subgroup analysis by menopausal and estrogen/progesterone receptor (ER/PR) status, smoking status and body mass index (BMI) were performed in order to detect potential confounders. Results: A total of 21 prospective studies were selected either for dose-response, the highest versus lowest category of consumption or subgroup analysis. The dose-response analysis of 13 prospective studies showed no significant association between coffee consumption and breast cancer risk in the non-linear model. However, an inverse relationship has been found when the analysis was restricted to post-menopausal women. Consumption of four cups of coffee per day was associated with a 10% reduction in postmenopausal cancer risk (relative risk, RR 0.90; 95% confidence interval, CI 0.82 to 0.99). Subgroup analyses showed consistent results for all potential confounding factors examined. Conclusions: Findings from this meta-analysis may support the hypothesis that coffee consumption is associated with decreased risk of postmenopausal breast cancer.
Original language | English |
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Article number | 112 |
Number of pages | 17 |
Journal | Nutrients |
Volume | 10 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2018 |
Keywords
- coffee
- caffeine
- breast cancer
- receptor
- postmenopausal
- dose-response
- meta-analysis
- METABOLIC SYNDROME
- TEA CONSUMPTION
- CAFFEINE INTAKE
- MOLECULAR-MECHANISMS
- TREND ESTIMATION
- NORWEGIAN WOMEN
- DIETARY PATTERN
- NO ASSOCIATION
- GREEN TEA
- HEALTH