Coffee Drinking and the Risk of Endometrial Cancer: An Updated Meta-Analysis of Observational Studies

Marko Lukic*, Neela Guha, Idlir Licaj, Piet A. van den Brandt, Leslie Thomas Stayner, Alessandra Tavani, Elisabete Weiderpass

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Background: Several compounds contained in coffee have been found to suppress carcinogenesis in experimental studies. We conducted a dose-response meta-analysis to assess the impact of coffee consumption on the risk of endometrial cancer. Materials and methods: We searched MEDLINE and EMBASE databases for studies published up to August 2016. Using random effects models, we estimated summary relative risks (RR) for cohort studies and odds ratios (OR) for case-control studies with 95% confidence intervals (CI). Dose-response analyses were conducted by using generalized least square trend estimation. Results: We identified 12 cohort studies and 8 case-control studies eligible for inclusion, contributing with 11,663 and 2,746 endometrial cancer cases, respectively. The summary RR for highest compared with lowest coffee intake was 0.74 (95% CI: 0.68-0.81; p(heterogeneity) = 0.09, I-2 = 32%). The corresponding summary RR among cohort studies was 0.78 (95% CI: 0.71-0.85; p(heterogeneity) = 0.14, I-2 = 31.9%) and 0.63 (95% CI: 0.53-0.76; p(heterogeneity) = 0.57, I-2 = 0%) for case-control studies. One-cup increment per day was associated with 3% risk reduction (95% CI: 2-4%) in cohort studies and 12% (95% CI: 5-18%) in case-control studies. After pooling the results from 5 cohort studies, the association remained significant only in women with body mass index over 30 (RR = 0.71, 95% CI: 0.61-0.81). Conclusion: The results from our meta-analysis strengthen the evidence of a protective effect of coffee consumption on the risk of EC and further suggest that increased coffee intake might be particularly beneficial for women with obesity.
Original languageEnglish
Pages (from-to)513-528
Number of pages16
JournalNutrition and Cancer-An International Journal
Volume70
Issue number4
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • DOSE-RESPONSE METAANALYSIS
  • PROSPECTIVE COHORT
  • DIETARY FACTORS
  • DECAFFEINATED COFFEE
  • POSTMENOPAUSAL WOMEN
  • CAFFEINE INTAKE
  • C-PEPTIDE
  • HORMONE CONCENTRATIONS
  • PUBLICATION BIAS
  • TREND ESTIMATION

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