Closing the 1-5 mu m size gap: Temperature-programmed, fed-batch synthesis of mu m-sized microgels

Agnieszka Natalia Ksiazkiewicz; Luise Bering; Falco Jung; Nadja Anna Wolter; Joern Viell; Alexander Mitsos; Andrij Pich

doi:10.1016/j.cej.2019.122293

Closing the 1-5 mu m size gap: Temperature-programmed, fed-batch synthesis of mu m-sized microgels

Agnieszka Natalia Ksiazkiewicz, Luise Bering, Falco Jung, Nadja Anna Wolter, Joern Viell, Alexander Mitsos, Andrij Pich^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Web of Science)

Abstract

Microgels below 1 mu m and above 20 mu m are readily accessible; however, obtaining them in size 1-10 mu m still remains a challenge. We present a surfactant-free precipitation polymerization approach, combining temperature-ramp (T-ramp) and fed-batch, generating 1-5 mu m in diameter poly(N-Vinylcaprolactam) (pVCL) microgels. Confocal microscopy and dynamic light scattering (DLS) confirm that the size of temperature-responsive pVCL microgels can be adjusted by the feeding ratio. The experimentally determined microgel sizes match the model-based predictions well. The developed synthesis method achieves high monomer conversions and provides high microgel yields as determined by Raman spectroscopy.

Original language	English
Article number	122293
Number of pages	6
Journal	Chemical Engineering Journal
Volume	379
DOIs	https://doi.org/10.1016/j.cej.2019.122293
Publication status	Published - 1 Jan 2020

Keywords

Micron-sized microgels
Fed-batch synthesis
Temperature-ramp
Poly(N-Vinylcaprolactam)
PRECIPITATION POLYMERIZATION
POLY(N-VINYLCAPROLACTAM)
PARTICLES
NANOGELS
DELIVERY

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10.1016/j.cej.2019.122293

Cite this

@article{7bd7cb245fbc4d47adb5abc8268fcca2,

title = "Closing the 1-5 mu m size gap: Temperature-programmed, fed-batch synthesis of mu m-sized microgels",

abstract = "Microgels below 1 mu m and above 20 mu m are readily accessible; however, obtaining them in size 1-10 mu m still remains a challenge. We present a surfactant-free precipitation polymerization approach, combining temperature-ramp (T-ramp) and fed-batch, generating 1-5 mu m in diameter poly(N-Vinylcaprolactam) (pVCL) microgels. Confocal microscopy and dynamic light scattering (DLS) confirm that the size of temperature-responsive pVCL microgels can be adjusted by the feeding ratio. The experimentally determined microgel sizes match the model-based predictions well. The developed synthesis method achieves high monomer conversions and provides high microgel yields as determined by Raman spectroscopy.",

keywords = "Micron-sized microgels, Fed-batch synthesis, Temperature-ramp, Poly(N-Vinylcaprolactam), PRECIPITATION POLYMERIZATION, POLY(N-VINYLCAPROLACTAM), PARTICLES, NANOGELS, DELIVERY",

author = "Ksiazkiewicz, {Agnieszka Natalia} and Luise Bering and Falco Jung and Wolter, {Nadja Anna} and Joern Viell and Alexander Mitsos and Andrij Pich",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/j.cej.2019.122293",

language = "English",

volume = "379",

journal = "Chemical Engineering Journal",

issn = "1385-8947",

publisher = "Excerpta Medica, Elsevier Science",

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TY - JOUR

T1 - Closing the 1-5 mu m size gap

T2 - Temperature-programmed, fed-batch synthesis of mu m-sized microgels

AU - Ksiazkiewicz, Agnieszka Natalia

AU - Bering, Luise

AU - Jung, Falco

AU - Wolter, Nadja Anna

AU - Viell, Joern

AU - Mitsos, Alexander

AU - Pich, Andrij

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Microgels below 1 mu m and above 20 mu m are readily accessible; however, obtaining them in size 1-10 mu m still remains a challenge. We present a surfactant-free precipitation polymerization approach, combining temperature-ramp (T-ramp) and fed-batch, generating 1-5 mu m in diameter poly(N-Vinylcaprolactam) (pVCL) microgels. Confocal microscopy and dynamic light scattering (DLS) confirm that the size of temperature-responsive pVCL microgels can be adjusted by the feeding ratio. The experimentally determined microgel sizes match the model-based predictions well. The developed synthesis method achieves high monomer conversions and provides high microgel yields as determined by Raman spectroscopy.

AB - Microgels below 1 mu m and above 20 mu m are readily accessible; however, obtaining them in size 1-10 mu m still remains a challenge. We present a surfactant-free precipitation polymerization approach, combining temperature-ramp (T-ramp) and fed-batch, generating 1-5 mu m in diameter poly(N-Vinylcaprolactam) (pVCL) microgels. Confocal microscopy and dynamic light scattering (DLS) confirm that the size of temperature-responsive pVCL microgels can be adjusted by the feeding ratio. The experimentally determined microgel sizes match the model-based predictions well. The developed synthesis method achieves high monomer conversions and provides high microgel yields as determined by Raman spectroscopy.

KW - Micron-sized microgels

KW - Fed-batch synthesis

KW - Temperature-ramp

KW - Poly(N-Vinylcaprolactam)

KW - PRECIPITATION POLYMERIZATION

KW - POLY(N-VINYLCAPROLACTAM)

KW - PARTICLES

KW - NANOGELS

KW - DELIVERY

U2 - 10.1016/j.cej.2019.122293

DO - 10.1016/j.cej.2019.122293

M3 - Article

VL - 379

JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

SN - 1385-8947

M1 - 122293

ER -