Closing the 1-5 mu m size gap: Temperature-programmed, fed-batch synthesis of mu m-sized microgels

Agnieszka Natalia Ksiazkiewicz, Luise Bering, Falco Jung, Nadja Anna Wolter, Joern Viell, Alexander Mitsos, Andrij Pich*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

Microgels below 1 mu m and above 20 mu m are readily accessible; however, obtaining them in size 1-10 mu m still remains a challenge. We present a surfactant-free precipitation polymerization approach, combining temperature-ramp (T-ramp) and fed-batch, generating 1-5 mu m in diameter poly(N-Vinylcaprolactam) (pVCL) microgels. Confocal microscopy and dynamic light scattering (DLS) confirm that the size of temperature-responsive pVCL microgels can be adjusted by the feeding ratio. The experimentally determined microgel sizes match the model-based predictions well. The developed synthesis method achieves high monomer conversions and provides high microgel yields as determined by Raman spectroscopy.

Original languageEnglish
Article number122293
Number of pages6
JournalChemical Engineering Journal
Volume379
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Micron-sized microgels
  • Fed-batch synthesis
  • Temperature-ramp
  • Poly(N-Vinylcaprolactam)
  • PRECIPITATION POLYMERIZATION
  • POLY(N-VINYLCAPROLACTAM)
  • PARTICLES
  • NANOGELS
  • DELIVERY

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