Closed-Loop Control of Arterial CO<inf>2</inf>for Neonatal Mechanical Ventilation: In-Vivo Interaction with Spontaneous Breathing

Valerie Pfannschmidt; Mateusz Buglowski; Matthias Hütten; Stefan Kowalewski; Mark Schoberer; André Stollenwerk

doi:10.1016/j.ifacol.2024.11.050

Closed-Loop Control of Arterial CO<inf>2</inf>for Neonatal Mechanical Ventilation: In-Vivo Interaction with Spontaneous Breathing

Valerie Pfannschmidt^*, Mateusz Buglowski, Matthias Hütten, Stefan Kowalewski, Mark Schoberer, André Stollenwerk

^*Corresponding author for this work

Research output: Contribution to journal › Conference article in journal › Academic › peer-review

Abstract

Mechanical ventilation of preterm neonates requires tight regulation of the arterial partial pressure of carbon dioxide (PaCO2), which can be achieved by a controller. A core challenge of such a controller is the interaction between automatically controlled mechanical ventilation and physiologically regulated spontaneous breathing. To include spontaneous breathing in the control loop, we extend our previously developed controller by the principle of Mandatory Minute Ventilation. In preliminary experiments with preterm lambs the controller behavior was adequate. Further evaluation and a more accurate estimation of PaCO2 are needed.

Original language	English
Pages (from-to)	281-286
Number of pages	6
Journal	IFAC-PapersOnLine
Volume	58
Issue number	24
DOIs	https://doi.org/10.1016/j.ifacol.2024.11.050
Publication status	Published - 1 Sept 2024
Event	12th IFAC Symposium on Biological and Medical Systems - Furtwangen University (HFU), Villingen-Schwenningen Duration: 11 Sept 2024 → 13 Sept 2024 Conference number: 12th https://www.bms-24.org/

Keywords

critical care
end-tidal carbon dioxide
experimental validation
mechanical ventilation
Physiological closed-loop control
preterm neonates

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10.1016/j.ifacol.2024.11.050

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title = "Closed-Loop Control of Arterial CO2for Neonatal Mechanical Ventilation: In-Vivo Interaction with Spontaneous Breathing",

abstract = "Mechanical ventilation of preterm neonates requires tight regulation of the arterial partial pressure of carbon dioxide (PaCO2), which can be achieved by a controller. A core challenge of such a controller is the interaction between automatically controlled mechanical ventilation and physiologically regulated spontaneous breathing. To include spontaneous breathing in the control loop, we extend our previously developed controller by the principle of Mandatory Minute Ventilation. In preliminary experiments with preterm lambs the controller behavior was adequate. Further evaluation and a more accurate estimation of PaCO2 are needed.",

keywords = "critical care, end-tidal carbon dioxide, experimental validation, mechanical ventilation, Physiological closed-loop control, preterm neonates",

author = "Valerie Pfannschmidt and Mateusz Buglowski and Matthias H{\"u}tten and Stefan Kowalewski and Mark Schoberer and Andr{\'e} Stollenwerk",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. This is an open access article under the CC BY-NC-ND license.; 12th IFAC Symposium on Biological and Medical Systems, BMS 2024 ; Conference date: 11-09-2024 Through 13-09-2024",

year = "2024",

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doi = "10.1016/j.ifacol.2024.11.050",

language = "English",

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pages = "281--286",

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T1 - Closed-Loop Control of Arterial CO2for Neonatal Mechanical Ventilation

T2 - 12th IFAC Symposium on Biological and Medical Systems

AU - Pfannschmidt, Valerie

AU - Buglowski, Mateusz

AU - Hütten, Matthias

AU - Kowalewski, Stefan

AU - Schoberer, Mark

AU - Stollenwerk, André

N1 - Conference code: 12th

PY - 2024/9/1

Y1 - 2024/9/1

N2 - Mechanical ventilation of preterm neonates requires tight regulation of the arterial partial pressure of carbon dioxide (PaCO2), which can be achieved by a controller. A core challenge of such a controller is the interaction between automatically controlled mechanical ventilation and physiologically regulated spontaneous breathing. To include spontaneous breathing in the control loop, we extend our previously developed controller by the principle of Mandatory Minute Ventilation. In preliminary experiments with preterm lambs the controller behavior was adequate. Further evaluation and a more accurate estimation of PaCO2 are needed.

AB - Mechanical ventilation of preterm neonates requires tight regulation of the arterial partial pressure of carbon dioxide (PaCO2), which can be achieved by a controller. A core challenge of such a controller is the interaction between automatically controlled mechanical ventilation and physiologically regulated spontaneous breathing. To include spontaneous breathing in the control loop, we extend our previously developed controller by the principle of Mandatory Minute Ventilation. In preliminary experiments with preterm lambs the controller behavior was adequate. Further evaluation and a more accurate estimation of PaCO2 are needed.

KW - critical care

KW - end-tidal carbon dioxide

KW - experimental validation

KW - mechanical ventilation

KW - Physiological closed-loop control

KW - preterm neonates

U2 - 10.1016/j.ifacol.2024.11.050

DO - 10.1016/j.ifacol.2024.11.050

M3 - Conference article in journal

SN - 2405-8963

VL - 58

SP - 281

EP - 286

JO - IFAC-PapersOnLine

JF - IFAC-PapersOnLine

IS - 24

Y2 - 11 September 2024 through 13 September 2024

ER -

Closed-Loop Control of Arterial CO<inf>2</inf>for Neonatal Mechanical Ventilation: In-Vivo Interaction with Spontaneous Breathing

Abstract

Keywords

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