Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions

Saivaroon Gajagowni; Steven Hopkins; Yusuf Qadeer; Salim S. Virani; Job A.J. Verdonschot; Catherine C. Coombs; Christopher I. Amos; Kevin T. Nead; Siddhartha Jaiswal; Chayakrit Krittanawong

doi:10.1016/j.pcad.2024.09.001

Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions

Saivaroon Gajagowni, Steven Hopkins, Yusuf Qadeer, Salim S. Virani, Job A.J. Verdonschot, Catherine C. Coombs, Christopher I. Amos, Kevin T. Nead, Siddhartha Jaiswal, Chayakrit Krittanawong^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden in CHIP, and CHIP itself effecting the incidence or prognosis of a variety of CVD. The purpose of this review is to understand the epidemiology, risk factors, and pathogenesis of CHIP in the context of various CVD conditions.

Original language	English
Pages (from-to)	79-85
Number of pages	7
Journal	Progress in Cardiovascular Diseases
Volume	86
Early online date	1 Jan 2024
DOIs	https://doi.org/10.1016/j.pcad.2024.09.001
Publication status	Published - 1 Sept 2024

Keywords

Atherosclerosis
Cardiovascular complications
CHIP
Clonal hematopoiesis of indeterminate potential

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10.1016/j.pcad.2024.09.001

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Gajagowni, S., Hopkins, S., Qadeer, Y., Virani, S. S., Verdonschot, J. A. J., Coombs, C. C., Amos, C. I., Nead, K. T., Jaiswal, S., & Krittanawong, C. (2024). Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions. Progress in Cardiovascular Diseases, 86, 79-85. https://doi.org/10.1016/j.pcad.2024.09.001

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title = "Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions",

abstract = "Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden in CHIP, and CHIP itself effecting the incidence or prognosis of a variety of CVD. The purpose of this review is to understand the epidemiology, risk factors, and pathogenesis of CHIP in the context of various CVD conditions.",

keywords = "Atherosclerosis, Cardiovascular complications, CHIP, Clonal hematopoiesis of indeterminate potential",

author = "Saivaroon Gajagowni and Steven Hopkins and Yusuf Qadeer and Virani, {Salim S.} and Verdonschot, {Job A.J.} and Coombs, {Catherine C.} and Amos, {Christopher I.} and Nead, {Kevin T.} and Siddhartha Jaiswal and Chayakrit Krittanawong",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = sep,

day = "1",

doi = "10.1016/j.pcad.2024.09.001",

language = "English",

volume = "86",

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journal = "Progress in Cardiovascular Diseases",

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Gajagowni, S, Hopkins, S, Qadeer, Y, Virani, SS, Verdonschot, JAJ, Coombs, CC, Amos, CI, Nead, KT, Jaiswal, S & Krittanawong, C 2024, 'Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions', Progress in Cardiovascular Diseases, vol. 86, pp. 79-85. https://doi.org/10.1016/j.pcad.2024.09.001

TY - JOUR

T1 - Clonal hematopoiesis of indeterminate potential and cardiovascular disease

T2 - Pathogenesis, clinical presentation, and future directions

AU - Gajagowni, Saivaroon

AU - Hopkins, Steven

AU - Qadeer, Yusuf

AU - Virani, Salim S.

AU - Verdonschot, Job A.J.

AU - Coombs, Catherine C.

AU - Amos, Christopher I.

AU - Nead, Kevin T.

AU - Jaiswal, Siddhartha

AU - Krittanawong, Chayakrit

PY - 2024/9/1

Y1 - 2024/9/1

N2 - Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden in CHIP, and CHIP itself effecting the incidence or prognosis of a variety of CVD. The purpose of this review is to understand the epidemiology, risk factors, and pathogenesis of CHIP in the context of various CVD conditions.

AB - Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden in CHIP, and CHIP itself effecting the incidence or prognosis of a variety of CVD. The purpose of this review is to understand the epidemiology, risk factors, and pathogenesis of CHIP in the context of various CVD conditions.

KW - Atherosclerosis

KW - Cardiovascular complications

KW - CHIP

KW - Clonal hematopoiesis of indeterminate potential

U2 - 10.1016/j.pcad.2024.09.001

DO - 10.1016/j.pcad.2024.09.001

M3 - (Systematic) Review article

SN - 0033-0620

VL - 86

SP - 79

EP - 85

JO - Progress in Cardiovascular Diseases

JF - Progress in Cardiovascular Diseases

ER -

Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions

Abstract

Keywords

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