Clinical value of (6)(8)Ga-DOTATATE-PET/CT compared to stand-alone contrast enhanced CT for the detection of extra-hepatic metastases in patients with neuroendocrine tumours (NET)

D.R. Albanus, J. Apitzsch, Z. Erdem, O. Erdem, F.A. Verburg, F.F. Behrendt, F.M. Mottaghy, A. Heinzel

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: To compare and outline the beneficial skills of combined (68)Ga-DOTATATE positron emission tomography (PET) with concurrent contrast enhanced X-ray computed tomography (ceCT) against stand-alone ceCT in 54 patients with neuroendocrine tumours (NET). METHODS: Patients with histologically confirmed NET and available follow-up of at least 6 months (median 12.6 months; range 6.1-23.2) were included. PET/CT and ceCT images were initially analyzed separately by two blinded nuclear medicine physicians and two radiologists, respectively. In a second step all four physicians reviewed all detected lesions together reaching a consensus-grading for PET/ceCT. The results were then compared to the reference standard consisting of clinical follow-up data. RESULTS: With regard to true positive lesions, PET/ceCT vs. stand alone ceCT detected 139 vs. 48 bone-lesions, 106 vs. 71 lymph node metastases and 26 vs. 26 pulmonary lesions. On a per-patient basis, PET/ceCT achieved a higher sensitivity (100% vs. 47%) and specificity (89% vs. 49%) for bone lesions than ceCT. For lymph nodes the effect was similar (sensitivity 92% vs. 64% and specificity 83% vs. 59%). For the detection of pulmonary lesions the sensitivity was identical (100%) while specificity of PET/ceCT was superior to ceCT-alone (95% vs. 82%). CONCLUSION: In summary, the use of (68)Ga-DOTATATE PET/ceCT leads to an increase in sensitivity and specificity in the detection of extra-hepatic NET metastases compared to stand-alone ceCT. Therefore, (68)Ga-DOTATATE PET/ceCT should be the imaging modality of choice in patients with NET.
Original languageEnglish
Pages (from-to)1866-1872
Number of pages7
JournalEuropean Journal of Radiology
Volume84
Issue number10
DOIs
Publication statusPublished - Oct 2015

Keywords

  • Ga-68-DOTA-TATE
  • PET/CT
  • Neuroendocrine tumour
  • Extra hepatic metastasis
  • GA-68-DOTA-TYR(3)-OCTREOTIDE PET
  • LIVER METASTASES
  • BONE METASTASES
  • SCINTIGRAPHY
  • GA-68-DOTA-TATE
  • GUIDELINES
  • SURVIVAL
  • DISEASE

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