Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

Jorge Labrador; Elisa Luno; Edo Vellenga; Salut Brunet; Jose Gonzalez-Campose; Maria C. Chillon; Aleksandra Holowiecka; Jordi Esteve; Juan Bergua; Jose D. Gonzalez-Sanmiguel; Cristina Gil; M. Tormo; Olga Salamero; Felix Manso; Isolda Fernandez; Javier de laSerna; Maria-Jose Moreno; M. Perez-Encinas; Isabel Krsnik; Josep-Maria Ribera; Jose Cervera; Maria J. Calasanz; Blanca Boluda; Marta Sobas; Bob Lowenberg; Miguel A. Sanz; Pau Montesinos; L. Palmer; null Fernandez; S. Ciarlo; F. Bezares; F. Rojas; H. Longoni; M. Gelemur; P. Fazio; C. Canepa; S. Saba; G. Balladares; P. Negri; M. Giunta; J. Milone; M. Prates; D. Lafalse; C. Sossa; F. Jaramillo; J. Mayer; F. Ramos; J. Martinez; M. R. de Groot; H. C. Schouten; PETHEMA Grp; HOVON Grp; PALG Grp; GATLA Grp

doi:10.1080/10428194.2018.1522438

Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

Jorge Labrador, Elisa Luno, Edo Vellenga, Salut Brunet, Jose Gonzalez-Campose, Maria C. Chillon, Aleksandra Holowiecka, Jordi Esteve, Juan Bergua, Jose D. Gonzalez-Sanmiguel, Cristina Gil, M. Tormo, Olga Salamero, Felix Manso, Isolda Fernandez, Javier de laSerna, Maria-Jose Moreno, M. Perez-Encinas, Isabel Krsnik, Josep-Maria RiberaJose Cervera, Maria J. Calasanz, Blanca Boluda, Marta Sobas, Bob Lowenberg, Miguel A. Sanz, Pau Montesinos^*, L. Palmer, Fernandez, S. Ciarlo, F. Bezares, F. Rojas, H. Longoni, M. Gelemur, P. Fazio, C. Canepa, S. Saba, G. Balladares, P. Negri, M. Giunta, J. Milone, M. Prates, D. Lafalse, C. Sossa, F. Jaramillo, J. Mayer, F. Ramos, J. Martinez, M. R. de Groot, H. C. Schouten, PETHEMA Grp, HOVON Grp, PALG Grp, GATLA Grp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1146-1155
Number of pages	10
Journal	Leukemia & Lymphoma
Volume	60
Issue number	5
DOIs	https://doi.org/10.1080/10428194.2018.1522438
Publication status	Published - 16 Apr 2019

Keywords

Acute promyelocytic leukemia
complex karyotype
ATRA
chemotherapy
prognostic
relapse
TRANS-RETINOIC ACID
ADDITIONAL CHROMOSOME-ABNORMALITIES
RISK-ADAPTED TREATMENT
ARSENIC TRIOXIDE
ANTHRACYCLINE MONOCHEMOTHERAPY
PROGNOSTIC-SIGNIFICANCE
CONSOLIDATION THERAPY
CYTOGENETIC CHANGES
FLT3 MUTATIONS
PETHEMA

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10.1080/10428194.2018.1522438

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Labrador, J., Luno, E., Vellenga, E., Brunet, S., Gonzalez-Campose, J., Chillon, M. C., Holowiecka, A., Esteve, J., Bergua, J., Gonzalez-Sanmiguel, J. D., Gil, C., Tormo, M., Salamero, O., Manso, F., Fernandez, I., de laSerna, J., Moreno, M-J., Perez-Encinas, M., Krsnik, I., ... GATLA Grp (2019). Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy. Leukemia & Lymphoma, 60(5), 1146-1155. https://doi.org/10.1080/10428194.2018.1522438

Labrador, Jorge ; Luno, Elisa ; Vellenga, Edo ; Brunet, Salut ; Gonzalez-Campose, Jose ; Chillon, Maria C. ; Holowiecka, Aleksandra ; Esteve, Jordi ; Bergua, Juan ; Gonzalez-Sanmiguel, Jose D. ; Gil, Cristina ; Tormo, M. ; Salamero, Olga ; Manso, Felix ; Fernandez, Isolda ; de laSerna, Javier ; Moreno, Maria-Jose ; Perez-Encinas, M. ; Krsnik, Isabel ; Ribera, Josep-Maria ; Cervera, Jose ; Calasanz, Maria J. ; Boluda, Blanca ; Sobas, Marta ; Lowenberg, Bob ; Sanz, Miguel A. ; Montesinos, Pau ; Palmer, L. ; Fernandez ; Ciarlo, S. ; Bezares, F. ; Rojas, F. ; Longoni, H. ; Gelemur, M. ; Fazio, P. ; Canepa, C. ; Saba, S. ; Balladares, G. ; Negri, P. ; Giunta, M. ; Milone, J. ; Prates, M. ; Lafalse, D. ; Sossa, C. ; Jaramillo, F. ; Mayer, J. ; Ramos, F. ; Martinez, J. ; de Groot, M. R. ; Schouten, H. C. ; PETHEMA Grp ; HOVON Grp ; PALG Grp ; GATLA Grp. / Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy. In: Leukemia & Lymphoma. 2019 ; Vol. 60, No. 5. pp. 1146-1155.

@article{d44f681eb4e94ee9836b86089a19546f,

title = "Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy",

keywords = "Acute promyelocytic leukemia, complex karyotype, ATRA, chemotherapy, prognostic, relapse, TRANS-RETINOIC ACID, ADDITIONAL CHROMOSOME-ABNORMALITIES, RISK-ADAPTED TREATMENT, ARSENIC TRIOXIDE, ANTHRACYCLINE MONOCHEMOTHERAPY, PROGNOSTIC-SIGNIFICANCE, CONSOLIDATION THERAPY, CYTOGENETIC CHANGES, FLT3 MUTATIONS, PETHEMA",

author = "Jorge Labrador and Elisa Luno and Edo Vellenga and Salut Brunet and Jose Gonzalez-Campose and Chillon, {Maria C.} and Aleksandra Holowiecka and Jordi Esteve and Juan Bergua and Gonzalez-Sanmiguel, {Jose D.} and Cristina Gil and M. Tormo and Olga Salamero and Felix Manso and Isolda Fernandez and {de laSerna}, Javier and Maria-Jose Moreno and M. Perez-Encinas and Isabel Krsnik and Josep-Maria Ribera and Jose Cervera and Calasanz, {Maria J.} and Blanca Boluda and Marta Sobas and Bob Lowenberg and Sanz, {Miguel A.} and Pau Montesinos and L. Palmer and Fernandez and S. Ciarlo and F. Bezares and F. Rojas and H. Longoni and M. Gelemur and P. Fazio and C. Canepa and S. Saba and G. Balladares and P. Negri and M. Giunta and J. Milone and M. Prates and D. Lafalse and C. Sossa and F. Jaramillo and J. Mayer and F. Ramos and J. Martinez and {de Groot}, {M. R.} and Schouten, {H. C.} and {PETHEMA Grp} and {HOVON Grp} and {PALG Grp} and {GATLA Grp}",

year = "2019",

month = apr,

day = "16",

doi = "10.1080/10428194.2018.1522438",

language = "English",

volume = "60",

pages = "1146--1155",

journal = "Leukemia & Lymphoma",

issn = "1042-8194",

publisher = "Routledge/Taylor & Francis Group",

number = "5",

}

Labrador, J, Luno, E, Vellenga, E, Brunet, S, Gonzalez-Campose, J, Chillon, MC, Holowiecka, A, Esteve, J, Bergua, J, Gonzalez-Sanmiguel, JD, Gil, C, Tormo, M, Salamero, O, Manso, F, Fernandez, I, de laSerna, J, Moreno, M-J, Perez-Encinas, M, Krsnik, I, Ribera, J-M, Cervera, J, Calasanz, MJ, Boluda, B, Sobas, M, Lowenberg, B, Sanz, MA, Montesinos, P, Palmer, L, Fernandez, Ciarlo, S, Bezares, F, Rojas, F, Longoni, H, Gelemur, M, Fazio, P, Canepa, C, Saba, S, Balladares, G, Negri, P, Giunta, M, Milone, J, Prates, M, Lafalse, D, Sossa, C, Jaramillo, F, Mayer, J, Ramos, F, Martinez, J, de Groot, MR, Schouten, HC, PETHEMA Grp, HOVON Grp, PALG Grp & GATLA Grp 2019, 'Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy', Leukemia & Lymphoma, vol. 60, no. 5, pp. 1146-1155. https://doi.org/10.1080/10428194.2018.1522438

Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy. / Labrador, Jorge; Luno, Elisa; Vellenga, Edo; Brunet, Salut; Gonzalez-Campose, Jose; Chillon, Maria C.; Holowiecka, Aleksandra; Esteve, Jordi; Bergua, Juan; Gonzalez-Sanmiguel, Jose D.; Gil, Cristina; Tormo, M.; Salamero, Olga; Manso, Felix; Fernandez, Isolda; de laSerna, Javier; Moreno, Maria-Jose; Perez-Encinas, M.; Krsnik, Isabel; Ribera, Josep-Maria; Cervera, Jose; Calasanz, Maria J.; Boluda, Blanca; Sobas, Marta; Lowenberg, Bob; Sanz, Miguel A.; Montesinos, Pau; Palmer, L.; Fernandez; Ciarlo, S.; Bezares, F.; Rojas, F.; Longoni, H.; Gelemur, M.; Fazio, P.; Canepa, C.; Saba, S.; Balladares, G.; Negri, P.; Giunta, M.; Milone, J.; Prates, M.; Lafalse, D.; Sossa, C.; Jaramillo, F.; Mayer, J.; Ramos, F.; Martinez, J.; de Groot, M. R.; Schouten, H. C.; PETHEMA Grp; HOVON Grp; PALG Grp; GATLA Grp.

In: Leukemia & Lymphoma, Vol. 60, No. 5, 16.04.2019, p. 1146-1155.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

AU - Labrador, Jorge

AU - Luno, Elisa

AU - Vellenga, Edo

AU - Brunet, Salut

AU - Gonzalez-Campose, Jose

AU - Chillon, Maria C.

AU - Holowiecka, Aleksandra

AU - Esteve, Jordi

AU - Bergua, Juan

AU - Gonzalez-Sanmiguel, Jose D.

AU - Gil, Cristina

AU - Tormo, M.

AU - Salamero, Olga

AU - Manso, Felix

AU - Fernandez, Isolda

AU - de laSerna, Javier

AU - Moreno, Maria-Jose

AU - Perez-Encinas, M.

AU - Krsnik, Isabel

AU - Ribera, Josep-Maria

AU - Cervera, Jose

AU - Calasanz, Maria J.

AU - Boluda, Blanca

AU - Sobas, Marta

AU - Lowenberg, Bob

AU - Sanz, Miguel A.

AU - Montesinos, Pau

AU - Palmer, L.

AU - Fernandez, null

AU - Ciarlo, S.

AU - Bezares, F.

AU - Rojas, F.

AU - Longoni, H.

AU - Gelemur, M.

AU - Fazio, P.

AU - Canepa, C.

AU - Saba, S.

AU - Balladares, G.

AU - Negri, P.

AU - Giunta, M.

AU - Milone, J.

AU - Prates, M.

AU - Lafalse, D.

AU - Sossa, C.

AU - Jaramillo, F.

AU - Mayer, J.

AU - Ramos, F.

AU - Martinez, J.

AU - de Groot, M. R.

AU - Schouten, H. C.

AU - PETHEMA Grp

AU - HOVON Grp

AU - PALG Grp

AU - GATLA Grp

PY - 2019/4/16

Y1 - 2019/4/16

KW - Acute promyelocytic leukemia

KW - complex karyotype

KW - ATRA

KW - chemotherapy

KW - prognostic

KW - relapse

KW - TRANS-RETINOIC ACID

KW - ADDITIONAL CHROMOSOME-ABNORMALITIES

KW - RISK-ADAPTED TREATMENT

KW - ARSENIC TRIOXIDE

KW - ANTHRACYCLINE MONOCHEMOTHERAPY

KW - PROGNOSTIC-SIGNIFICANCE

KW - CONSOLIDATION THERAPY

KW - CYTOGENETIC CHANGES

KW - FLT3 MUTATIONS

KW - PETHEMA

U2 - 10.1080/10428194.2018.1522438

DO - 10.1080/10428194.2018.1522438

M3 - Article

VL - 60

SP - 1146

EP - 1155

JO - Leukemia & Lymphoma

JF - Leukemia & Lymphoma

SN - 1042-8194

IS - 5

ER -