Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology

J. M. Oettrich, V. T. Dao, J. Frijhoff, P. W. M. Kleikers, Ana Casas Guijarro, A. J. Hobbs, H. H. H. W. Schmidt*

*Corresponding author for this work

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Abstract

Therapies that modulate cyclic guanosine-30-50-monophosphate (cGMP) have emerged as one of the most successful areas in recent drug discovery and clinical pharmacology. Historically, their focus has been on cardiovascular disease phenotypes; however, cGMP's relevance is likely to go beyond this rather limited organ-based set of indications. Moreover, the multitude of targets and their apparent interchangeability is a proof-of-concept of network pharmacology.
Original languageEnglish
Pages (from-to)360-362
JournalClinical Pharmacology & Therapeutics
Volume99
Issue number4
DOIs
Publication statusPublished - Apr 2016

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