TY - JOUR
T1 - Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19
AU - Heesakkers, H.
AU - van der Hoeven, J.G.
AU - Corsten, S.
AU - Janssen, I.
AU - Ewalds, E.
AU - Simons, K.S.
AU - Westerhof, B.
AU - Rettig, T.C.D.
AU - Jacobs, C.
AU - van Santen, S.
AU - Slooter, A.J.C.
AU - van der Woude, M.C.E.
AU - van den Boogaard, M.
AU - Zegers, M.
N1 - Publisher Copyright:
© 2022 American Medical Association. All rights reserved.
PY - 2022/2/8
Y1 - 2022/2/8
N2 - IMPORTANCE One-year outcomes in patients who have had COVID-19 and who received treatment in the intensive care unit (ICU) are unknown.OBJECTIVE To assess the occurrence of physical, mental, and cognitive symptoms among patients with COVID-19 at 1 year after ICU treatment.DESIGN, SETTING, AND PARTICIPANTS An exploratory prospective multicenter cohort study conducted in ICUs of 11 Dutch hospitals. Patients (N = 452) with COVID-19, aged 16 years and older, and alive after hospital discharge following admission to 1 of the 11 ICUs during the first COVID-19 surge (March 1, 2020, until July 1, 2020) were eligible for inclusion. Patients were followed up for 1 year, and the date of final follow-up was June 16, 2021.EXPOSURES Patients with COVID-19 who received ICU treatment and survived 1 year after ICU admission.MAIN OUTCOMES AND MEASURES The main outcomes were self-reported occurrence of physical symptoms (frailty [Clinical Frailty Scale score >= 5], fatigue [Checklist Individual Strength-fatigue subscale score >= 27], physical problems), mental symptoms (anxiety [Hospital Anxiety and Depression {HADS} subscale score >= 8], depression [HADS subscale score >= 8], posttraumatic stress disorder [mean Impact of Event Scale score >= 1.75]), and cognitive symptoms (Cognitive Failure Questionnaire-14 score >= 43) 1 year after ICU treatment and measured with validated questionnaires.RESULTS Of the 452 eligible patients, 301 (66.8%) patients could be included, and 246 (81.5%) patients (mean [SD] age, 61.2 [9.3] years; 176 men [71.5%]; median ICU stay, 18 days [IQR, 11 to 32]) completed the 1-year follow-up questionnaires. At 1 year after ICU treatment for COVID-19, physical symptoms were reported by 182 of 245 patients (74.3% [95% CI, 68.3% to 79.6%]), mental symptoms were reported by 64 of 244 patients (26.2% [95% CI, 20.8% to 32.2%]), and cognitive symptoms were reported by 39 of 241 patients (16.2% [95% CI, 11.8% to 21.5%]). The most frequently reported new physical problems were weakened condition (95/244 patients [38.9%]), joint stiffness (64/243 patients [26.3%]) joint pain (62/243 patients [25.5%]), muscle weakness (60/242 patients [24.8%]) and myalgia (52/244 patients [21.3%]).CONCLUSIONS AND RELEVANCE In this exploratory study of patients in 11 Dutch hospitals who survived 1 year following ICU treatment for COVID-19, physical, mental, or cognitive symptoms were frequently reported.
AB - IMPORTANCE One-year outcomes in patients who have had COVID-19 and who received treatment in the intensive care unit (ICU) are unknown.OBJECTIVE To assess the occurrence of physical, mental, and cognitive symptoms among patients with COVID-19 at 1 year after ICU treatment.DESIGN, SETTING, AND PARTICIPANTS An exploratory prospective multicenter cohort study conducted in ICUs of 11 Dutch hospitals. Patients (N = 452) with COVID-19, aged 16 years and older, and alive after hospital discharge following admission to 1 of the 11 ICUs during the first COVID-19 surge (March 1, 2020, until July 1, 2020) were eligible for inclusion. Patients were followed up for 1 year, and the date of final follow-up was June 16, 2021.EXPOSURES Patients with COVID-19 who received ICU treatment and survived 1 year after ICU admission.MAIN OUTCOMES AND MEASURES The main outcomes were self-reported occurrence of physical symptoms (frailty [Clinical Frailty Scale score >= 5], fatigue [Checklist Individual Strength-fatigue subscale score >= 27], physical problems), mental symptoms (anxiety [Hospital Anxiety and Depression {HADS} subscale score >= 8], depression [HADS subscale score >= 8], posttraumatic stress disorder [mean Impact of Event Scale score >= 1.75]), and cognitive symptoms (Cognitive Failure Questionnaire-14 score >= 43) 1 year after ICU treatment and measured with validated questionnaires.RESULTS Of the 452 eligible patients, 301 (66.8%) patients could be included, and 246 (81.5%) patients (mean [SD] age, 61.2 [9.3] years; 176 men [71.5%]; median ICU stay, 18 days [IQR, 11 to 32]) completed the 1-year follow-up questionnaires. At 1 year after ICU treatment for COVID-19, physical symptoms were reported by 182 of 245 patients (74.3% [95% CI, 68.3% to 79.6%]), mental symptoms were reported by 64 of 244 patients (26.2% [95% CI, 20.8% to 32.2%]), and cognitive symptoms were reported by 39 of 241 patients (16.2% [95% CI, 11.8% to 21.5%]). The most frequently reported new physical problems were weakened condition (95/244 patients [38.9%]), joint stiffness (64/243 patients [26.3%]) joint pain (62/243 patients [25.5%]), muscle weakness (60/242 patients [24.8%]) and myalgia (52/244 patients [21.3%]).CONCLUSIONS AND RELEVANCE In this exploratory study of patients in 11 Dutch hospitals who survived 1 year following ICU treatment for COVID-19, physical, mental, or cognitive symptoms were frequently reported.
KW - HOSPITAL ANXIETY
KW - DEPRESSION SCALE
KW - RECOVERY
KW - ILLNESS
KW - FRAILTY
KW - IMPACT
U2 - 10.1001/jama.2022.0040
DO - 10.1001/jama.2022.0040
M3 - Article
C2 - 35072716
SN - 0098-7484
VL - 327
SP - 559
EP - 565
JO - JAMA-Journal of the American Medical Association
JF - JAMA-Journal of the American Medical Association
IS - 6
ER -