Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

Amelie Echle; Heike Irmgard Grabsch; Philip Quirke; Piet A. van den Brandt; Nicholas P. West; Gordon G. A. Hutchins; Lara R. Heij; Xiuxiang Tan; Susan D. Richman; Jeremias Krause; Elizabeth Alwers; Josien Jenniskens; Kelly Offermans; Richard Gray; Hermann Brenner; Jenny Chang-Claude; Christian Trautwein; Alexander T. Pearson; Peter Boor; Tom Luedde; Nadine Therese Gaisa; Michael Hoffmeister; Jakob Nikolas Kather

doi:10.1053/j.gastro.2020.06.021

Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

Amelie Echle, Heike Irmgard Grabsch, Philip Quirke, Piet A. van den Brandt, Nicholas P. West, Gordon G. A. Hutchins, Lara R. Heij, Xiuxiang Tan, Susan D. Richman, Jeremias Krause, Elizabeth Alwers, Josien Jenniskens, Kelly Offermans, Richard Gray, Hermann Brenner, Jenny Chang-Claude, Christian Trautwein, Alexander T. Pearson, Peter Boor, Tom LueddeNadine Therese Gaisa, Michael Hoffmeister, Jakob Nikolas Kather^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1406-1416.e11
Number of pages	22
Journal	Gastroenterology
Volume	159
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2020.06.021
Publication status	Published - Oct 2020

Keywords

biomarker
cancer immunotherapy
Lynch syndrome
mutation
MISMATCH-REPAIR GENES
MOLECULAR CHARACTERIZATION
CANCER
COLON

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Echle, A., Grabsch, H. I., Quirke, P., van den Brandt, P. A., West, N. P., Hutchins, G. G. A., Heij, L. R., Tan, X., Richman, S. D., Krause, J., Alwers, E., Jenniskens, J., Offermans, K., Gray, R., Brenner, H., Chang-Claude, J., Trautwein, C., Pearson, A. T., Boor, P., ... Kather, J. N. (2020). Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. Gastroenterology, 159(4), 1406-1416.e11. https://doi.org/10.1053/j.gastro.2020.06.021

Echle, Amelie ; Grabsch, Heike Irmgard ; Quirke, Philip ; van den Brandt, Piet A. ; West, Nicholas P. ; Hutchins, Gordon G. A. ; Heij, Lara R. ; Tan, Xiuxiang ; Richman, Susan D. ; Krause, Jeremias ; Alwers, Elizabeth ; Jenniskens, Josien ; Offermans, Kelly ; Gray, Richard ; Brenner, Hermann ; Chang-Claude, Jenny ; Trautwein, Christian ; Pearson, Alexander T. ; Boor, Peter ; Luedde, Tom ; Gaisa, Nadine Therese ; Hoffmeister, Michael ; Kather, Jakob Nikolas. / Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. In: Gastroenterology. 2020 ; Vol. 159, No. 4. pp. 1406-1416.e11.

@article{868ad9205a504c6db8bc593a1dc88892,

title = "Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning",

keywords = "biomarker, cancer immunotherapy, Lynch syndrome, mutation, MISMATCH-REPAIR GENES, MOLECULAR CHARACTERIZATION, CANCER, COLON",

author = "Amelie Echle and Grabsch, {Heike Irmgard} and Philip Quirke and {van den Brandt}, {Piet A.} and West, {Nicholas P.} and Hutchins, {Gordon G. A.} and Heij, {Lara R.} and Xiuxiang Tan and Richman, {Susan D.} and Jeremias Krause and Elizabeth Alwers and Josien Jenniskens and Kelly Offermans and Richard Gray and Hermann Brenner and Jenny Chang-Claude and Christian Trautwein and Pearson, {Alexander T.} and Peter Boor and Tom Luedde and Gaisa, {Nadine Therese} and Michael Hoffmeister and Kather, {Jakob Nikolas}",

year = "2020",

month = oct,

doi = "10.1053/j.gastro.2020.06.021",

language = "English",

volume = "159",

pages = "1406--1416.e11",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "Elsevier Saunders",

number = "4",

}

Echle, A, Grabsch, HI, Quirke, P, van den Brandt, PA, West, NP, Hutchins, GGA, Heij, LR, Tan, X, Richman, SD, Krause, J, Alwers, E, Jenniskens, J , Offermans, K, Gray, R, Brenner, H, Chang-Claude, J, Trautwein, C, Pearson, AT, Boor, P, Luedde, T, Gaisa, NT, Hoffmeister, M & Kather, JN 2020, 'Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning', Gastroenterology, vol. 159, no. 4, pp. 1406-1416.e11. https://doi.org/10.1053/j.gastro.2020.06.021

Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. / Echle, Amelie; Grabsch, Heike Irmgard; Quirke, Philip; van den Brandt, Piet A.; West, Nicholas P.; Hutchins, Gordon G. A.; Heij, Lara R.; Tan, Xiuxiang; Richman, Susan D.; Krause, Jeremias; Alwers, Elizabeth; Jenniskens, Josien ; Offermans, Kelly; Gray, Richard; Brenner, Hermann; Chang-Claude, Jenny; Trautwein, Christian; Pearson, Alexander T.; Boor, Peter; Luedde, Tom; Gaisa, Nadine Therese; Hoffmeister, Michael; Kather, Jakob Nikolas.

In: Gastroenterology, Vol. 159, No. 4, 10.2020, p. 1406-1416.e11.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

AU - Echle, Amelie

AU - Grabsch, Heike Irmgard

AU - Quirke, Philip

AU - van den Brandt, Piet A.

AU - West, Nicholas P.

AU - Hutchins, Gordon G. A.

AU - Heij, Lara R.

AU - Tan, Xiuxiang

AU - Richman, Susan D.

AU - Krause, Jeremias

AU - Alwers, Elizabeth

AU - Jenniskens, Josien

AU - Offermans, Kelly

AU - Gray, Richard

AU - Brenner, Hermann

AU - Chang-Claude, Jenny

AU - Trautwein, Christian

AU - Pearson, Alexander T.

AU - Boor, Peter

AU - Luedde, Tom

AU - Gaisa, Nadine Therese

AU - Hoffmeister, Michael

AU - Kather, Jakob Nikolas

PY - 2020/10

Y1 - 2020/10

KW - biomarker

KW - cancer immunotherapy

KW - Lynch syndrome

KW - mutation

KW - MISMATCH-REPAIR GENES

KW - MOLECULAR CHARACTERIZATION

KW - CANCER

KW - COLON

U2 - 10.1053/j.gastro.2020.06.021

DO - 10.1053/j.gastro.2020.06.021

M3 - Article

C2 - 32562722

VL - 159

SP - 1406-1416.e11

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 4

ER -