TY - JOUR
T1 - Clinical features of Chinese patients with relapsing polychondritis
AU - Yang, Peizeng
AU - Yuan, Wen
AU - Du, Liping
AU - Zhou, Qingyun
AU - Wang, Chaokui
AU - Ye, Zi
AU - Kijlstra, Aize
PY - 2019/8
Y1 - 2019/8
N2 - Purpose To characterise the ocular and extraocular findings in patients with relapsing polychondritis (RP) patients. Design Retrospective, longitudinal study. Methods A total number of 16 patients with ocular RP, seen in our tertiary uveitis referral centre over a time period of 10 years were included in this study. Routine ocular examinations such as best-corrected visual acuity, intraocular pressure, slit-lamp biomicroscopy, ophthalmoscopy and auxiliary examinations including ultrasound biomicroscopy, B-scanultrasonography, fundus fluorescein angiography and optical coherence tomography were performed. Ocular and systemic manifestations of these 16 patients were analysed and compared with those presented by others. The patients were treated by corticosteroids or in combination with immunosuppressive agents. Results Eleven male and five female patients were included with a mean age of 40.4 years. Ocular involvement was bilateral in 75% of the patients and manifested as scleritis (n=10) or uveitis (n=6). Generalised, anterior and posterior uveitis was found in three, two and one patients, respectively. The frequencies of inner ear involvement and arthritis were lower in Chinese patients compared with that observed in Caucasians. Nine patients had a follow-up of 2-44 months, and in these individuals a better visual prognosis was observed in female patients compared with males. Conclusions Our study shows that uveitis associated with RP may manifest as generalised, anterior or posterior uveitis. The incidence of inner ear involvement and arthritis in these patients was lower than that in Caucasians. Female patients seem to have milder inflammation and a better visual prognosis.
AB - Purpose To characterise the ocular and extraocular findings in patients with relapsing polychondritis (RP) patients. Design Retrospective, longitudinal study. Methods A total number of 16 patients with ocular RP, seen in our tertiary uveitis referral centre over a time period of 10 years were included in this study. Routine ocular examinations such as best-corrected visual acuity, intraocular pressure, slit-lamp biomicroscopy, ophthalmoscopy and auxiliary examinations including ultrasound biomicroscopy, B-scanultrasonography, fundus fluorescein angiography and optical coherence tomography were performed. Ocular and systemic manifestations of these 16 patients were analysed and compared with those presented by others. The patients were treated by corticosteroids or in combination with immunosuppressive agents. Results Eleven male and five female patients were included with a mean age of 40.4 years. Ocular involvement was bilateral in 75% of the patients and manifested as scleritis (n=10) or uveitis (n=6). Generalised, anterior and posterior uveitis was found in three, two and one patients, respectively. The frequencies of inner ear involvement and arthritis were lower in Chinese patients compared with that observed in Caucasians. Nine patients had a follow-up of 2-44 months, and in these individuals a better visual prognosis was observed in female patients compared with males. Conclusions Our study shows that uveitis associated with RP may manifest as generalised, anterior or posterior uveitis. The incidence of inner ear involvement and arthritis in these patients was lower than that in Caucasians. Female patients seem to have milder inflammation and a better visual prognosis.
KW - immunology
KW - iris
KW - inflammation
KW - imaging
U2 - 10.1136/bjophthalmol-2018-312660
DO - 10.1136/bjophthalmol-2018-312660
M3 - Article
VL - 103
SP - 1129
EP - 1132
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 8
ER -