TY - JOUR
T1 - Clinical Decision Rules for Excluding Pulmonary Embolism: A Meta-analysis
AU - Lucassen, Wim A. M.
AU - Geersing, Geert-Jan
AU - Erkens, Petra M. G.
AU - Reitsma, Johannes B.
AU - Moons, Karel G. M.
AU - Buller, Harry R.
AU - van Weert, Henk C. P. M.
PY - 2011/10/4
Y1 - 2011/10/4
N2 - Background: Clinical probability assessment is combined with D-dimer testing to exclude pulmonary embolism (PE). Purpose: To compare the test characteristics of gestalt (a physician's unstructured estimate) and clinical decision rules for evaluating adults with suspected PE and assess the failure rate of gestalt and rules when used in combination with D-dimer testing. Data Sources: Articles in MEDLINE and EMBASE in English, French, German, Italian, Spanish, or Dutch that were published between 1966 and June 2011. Study Selection: 3 reviewers, working in pairs, selected prospective studies in consecutive patients suspected of having PE. Studies had to estimate the probability of PE by using gestalt or a decision rule and verify the diagnosis by using an appropriate reference standard. Data Extraction: Data on study characteristics, test performance, and prevalence were extracted. Reviewers constructed 2 x 2 tables and assessed the methodological quality of the studies. Data Synthesis: 52 studies, comprising 55 268 patients, were selected. Meta-analysis was performed on studies that used gestalt (15 studies; sensitivity, 0.85; specificity, 0.51), the Wells rule with a cutoff value less than 2 (19 studies; sensitivity, 0.84; specificity, 0.58) or 4 or less (11 studies; sensitivity, 0.60; specificity, 0.80), the Geneva rule (5 studies; sensitivity, 0.84; specificity, 0.50), and the revised Geneva rule (4 studies; sensitivity, 0.91; specificity, 0.37). An increased prevalence of PE was associated with higher sensitivity and lower specificity. Combining a decision rule or gestalt with D-dimer testing seemed safe for all strategies, except when the less-sensitive Wells rule (cutoff value
AB - Background: Clinical probability assessment is combined with D-dimer testing to exclude pulmonary embolism (PE). Purpose: To compare the test characteristics of gestalt (a physician's unstructured estimate) and clinical decision rules for evaluating adults with suspected PE and assess the failure rate of gestalt and rules when used in combination with D-dimer testing. Data Sources: Articles in MEDLINE and EMBASE in English, French, German, Italian, Spanish, or Dutch that were published between 1966 and June 2011. Study Selection: 3 reviewers, working in pairs, selected prospective studies in consecutive patients suspected of having PE. Studies had to estimate the probability of PE by using gestalt or a decision rule and verify the diagnosis by using an appropriate reference standard. Data Extraction: Data on study characteristics, test performance, and prevalence were extracted. Reviewers constructed 2 x 2 tables and assessed the methodological quality of the studies. Data Synthesis: 52 studies, comprising 55 268 patients, were selected. Meta-analysis was performed on studies that used gestalt (15 studies; sensitivity, 0.85; specificity, 0.51), the Wells rule with a cutoff value less than 2 (19 studies; sensitivity, 0.84; specificity, 0.58) or 4 or less (11 studies; sensitivity, 0.60; specificity, 0.80), the Geneva rule (5 studies; sensitivity, 0.84; specificity, 0.50), and the revised Geneva rule (4 studies; sensitivity, 0.91; specificity, 0.37). An increased prevalence of PE was associated with higher sensitivity and lower specificity. Combining a decision rule or gestalt with D-dimer testing seemed safe for all strategies, except when the less-sensitive Wells rule (cutoff value
U2 - 10.7326/0003-4819-155-7-201110040-00007
DO - 10.7326/0003-4819-155-7-201110040-00007
M3 - Article
C2 - 21969343
SN - 0003-4819
VL - 155
SP - 448-U94
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 7
ER -