Clinical Decision Rules for Excluding Pulmonary Embolism: A Meta-analysis

Wim A. M. Lucassen*, Geert-Jan Geersing, Petra M. G. Erkens, Johannes B. Reitsma, Karel G. M. Moons, Harry R. Buller, Henk C. P. M. van Weert

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Clinical probability assessment is combined with D-dimer testing to exclude pulmonary embolism (PE). Purpose: To compare the test characteristics of gestalt (a physician's unstructured estimate) and clinical decision rules for evaluating adults with suspected PE and assess the failure rate of gestalt and rules when used in combination with D-dimer testing. Data Sources: Articles in MEDLINE and EMBASE in English, French, German, Italian, Spanish, or Dutch that were published between 1966 and June 2011. Study Selection: 3 reviewers, working in pairs, selected prospective studies in consecutive patients suspected of having PE. Studies had to estimate the probability of PE by using gestalt or a decision rule and verify the diagnosis by using an appropriate reference standard. Data Extraction: Data on study characteristics, test performance, and prevalence were extracted. Reviewers constructed 2 x 2 tables and assessed the methodological quality of the studies. Data Synthesis: 52 studies, comprising 55 268 patients, were selected. Meta-analysis was performed on studies that used gestalt (15 studies; sensitivity, 0.85; specificity, 0.51), the Wells rule with a cutoff value less than 2 (19 studies; sensitivity, 0.84; specificity, 0.58) or 4 or less (11 studies; sensitivity, 0.60; specificity, 0.80), the Geneva rule (5 studies; sensitivity, 0.84; specificity, 0.50), and the revised Geneva rule (4 studies; sensitivity, 0.91; specificity, 0.37). An increased prevalence of PE was associated with higher sensitivity and lower specificity. Combining a decision rule or gestalt with D-dimer testing seemed safe for all strategies, except when the less-sensitive Wells rule (cutoff value
Original languageEnglish
Pages (from-to)448-U94
JournalAnnals of Internal Medicine
Issue number7
Publication statusPublished - 4 Oct 2011


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